about
Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system.Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse modelsTransient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancerCapillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnosticsModeling metastasis biology and therapy in real time in the mouse lung.Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression.Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancerExpression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics.TGF-beta signaling in mammary gland development and tumorigenesis.Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.SDF-1α mediates wound-promoted tumor growth in a syngeneic orthotopic mouse model of breast cancer.Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effectsBone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancerA flexible reporter system for direct observation and isolation of cancer stem cellsA novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary glandChemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cellsExpression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effectsA mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death.Distribution and modulation of the cellular receptor for transforming growth factor-betaDisruption of transforming growth factor beta signaling by a novel ligand-dependent mechanismTGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injuryTransforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft modelProgressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism.Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium.Effective chemoimmunotherapy with anti-TGFβ antibody and cyclophosphamide in a mouse model of breast cancer.A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.Beyond TGFβ: roles of other TGFβ superfamily members in cancer.Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational efficiency.Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.Transforming growth factor-beta: biological function and chemical structureTransforming growth factor-beta: multifunctional regulator of cell growth and phenotype
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Lalage M Wakefield
@ast
Lalage M Wakefield
@en
Lalage M Wakefield
@es
Lalage M Wakefield
@nl
type
label
Lalage M Wakefield
@ast
Lalage M Wakefield
@en
Lalage M Wakefield
@es
Lalage M Wakefield
@nl
prefLabel
Lalage M Wakefield
@ast
Lalage M Wakefield
@en
Lalage M Wakefield
@es
Lalage M Wakefield
@nl
P106
P31
P496
0000-0003-4124-5250