about
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNAInsight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleasesStructural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNAThe 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae.Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityStep-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase.Recognition of damaged DNA by Escherichia coli Fpg protein: insights from structural and kinetic data.New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA.Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells.Enzymology of repair of etheno-adducts.7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.Thermodynamic, kinetic, and structural basis for recognition and repair of 8-oxoguanine in DNA by Fpg protein from Escherichia coli.Conformational Dynamics of DNA Repair by Escherichia coli Endonuclease IIIHigh resolution characterization of formamidopyrimidine-DNA glycosylase interaction with its substrate by chemical cross-linking and mass spectrometry using substrate analogs.Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA.Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta.TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway.Initiation of 8-oxoguanine base excision repair within trinucleotide tandem repeats.The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells.Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis.The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA.Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals.A molecular beacon assay for measuring base excision repair activities.Coupling of the nucleotide incision and 3'-->5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences.Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase.Presence of base excision repair enzymes in the wheat aleurone and their activation in cells undergoing programmed cell death.Substrate specificity of homogeneous monkeypox virus uracil-DNA glycosylase.Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells.Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1.Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1.Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alexander A Ishchenko
@ast
Alexander A Ishchenko
@es
Alexander A Ishchenko
@nl
Alexander Anatoljewitsch Ischtschenko
@de
Alexander Ishchenko
@en
Александр Анатольевич Ищенко
@ru
type
label
Alexander A Ishchenko
@ast
Alexander A Ishchenko
@es
Alexander A Ishchenko
@nl
Alexander Anatoljewitsch Ischtschenko
@de
Alexander Ishchenko
@en
Александр Анатольевич Ищенко
@ru
altLabel
Aleksandr Anatolyevich Ishchenko
@en
Aleksandr Ishchenko
@en
Alexander A Ishchenko
@en
Alexander Ischtschenko
@de
prefLabel
Alexander A Ishchenko
@ast
Alexander A Ishchenko
@es
Alexander A Ishchenko
@nl
Alexander Anatoljewitsch Ischtschenko
@de
Alexander Ishchenko
@en
Александр Анатольевич Ищенко
@ru
P106
P21
P31
P496
0000-0002-0488-8858