about
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanismNovel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screeningDNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus.Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges.Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase II in reconstituted simian virus 40 chromatin.Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.A rational selection of drug targets needs deeper insights into general regulation mechanisms.Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active PromotersDiscovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I.DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity.A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors.Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.Type I DNA Topoisomerases.Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation.Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.Effects of common buffer systems on drug activity: the case of clerocidin.Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation.Mechanism of action of DNA topoisomerase inhibitors.Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo.MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance.A study of cross-resistance pattern and expression of molecular markers of multidrug resistance in a human small-cell lung-cancer cell line selected with doxorubicin.A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.New developments in antitumor anthracyclines.Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line.Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins.Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion.Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells.Interaction model for anthracycline activity against DNA topoisomerase II.RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Giovanni Capranico
@ast
Giovanni Capranico
@en
Giovanni Capranico
@es
Giovanni Capranico
@nl
type
label
Giovanni Capranico
@ast
Giovanni Capranico
@en
Giovanni Capranico
@es
Giovanni Capranico
@nl
prefLabel
Giovanni Capranico
@ast
Giovanni Capranico
@en
Giovanni Capranico
@es
Giovanni Capranico
@nl
P106
P1153
7007057112
P21
P31
P496
0000-0002-8708-6454