Can BSEP Inhibition Testing In Drug Discovery And Development Reduce Liver Injury Risk? - An International Transporter Consortium Perspective

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Can BSEP Inhibition Testing In Drug Discovery And Development Reduce Liver Injury Risk? - An International Transporter Consortium Perspective

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http://www.wikidata.org/entity/Q57111135

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article

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im November 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

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Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

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Item

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Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

@en

Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

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Can Bile Salt Export Pump Inhi ...... sporter Consortium Perspective

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Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

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Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

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P1476

Can BSEP Inhibition Testing In ...... sporter Consortium Perspective

@en

P2093

A David Rodrigues

http://www.w3.org/2001/XMLSchema#string

Christina Battista

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Christoph Funk

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David Dai

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David L Bourdet

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J Gerry Kenna

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Jenny M Pedersen

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Jonathan Maher

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Joseph W Polli

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Kenneth R Brouwer

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P275

Creative Commons Attribution-NonCommercial

P2860

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump

The bile salt export pump

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

Comparative hepatotoxicity of cholic acid, deoxycholic acid and lithocholic acid in the rat: in vivo and in vitro studies

Integrating cellular metabolism into a multiscale whole-body model

P304

916-932

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P31

scholarly article

review article

P356

10.1002/CPT.1222

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P407

English

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P478

104

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P577

2018-08-23T00:00:00Z

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2018-11-01T00:00:00Z

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P698

30137645

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P921

Farmakologi

mechanism of action

membrane proteins

fluids and secretions

Amathumbu

P932

6220754

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