High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
about
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFPPTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alphaIdentification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivatorRegulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifenOral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in ratsMir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNATransgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cellsEndocrinology and hormone therapy in breast cancer: new insight into estrogen receptor-alpha function and its implication for endocrine therapy resistance in breast cancerNew targets for the antitumor activity of gambogic acid in hematologic malignanciesSRC-3 has a role in cancer other than as a nuclear receptor coactivator.Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer.Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and DeathPELP1 overexpression in the mouse mammary gland results in the development of hyperplasia and carcinomaGene amplification and associated loss of 5' regulatory sequences of CoAA in human cancersFunctional implications of altered subcellular localization of PELP1 in breast cancer cells.Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancerSRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migrationOncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptorDevelopment of a novel molecular sensor for imaging estrogen receptor-coactivator protein-protein interactionsPrior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast CancerSYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 proteinProtective effect of higenamine ameliorates collagen-induced arthritis through heme oxygenase-1 and PI3K/Akt/Nrf-2 signaling pathwaysPerturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation.Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expressionIntegrative genome-wide expression analysis bears evidence of estrogen receptor-independent transcription in heregulin-stimulated MCF-7 cells.The UPS: a promising target for breast cancer treatment.Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Genetically engineered ERα-positive breast cancer mouse models.Increased radiosensitivity and radiation-induced apoptosis in SRC-3 knockout mice.The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC‑3 knockout mice.Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic miceDeficiency in steroid receptor coactivator 3 enhances cytokine production in IgE-stimulated mast cells and passive systemic anaphylaxis in mice.Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α.Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complexThe levels of RAC3 expression are up regulated by TNF in the inflammatory response.Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.Global characterization of transcriptional impact of the SRC-3 coregulator
P2860
Q24303428-EE835DD2-8313-4A9D-B3CA-62676FBF1463Q24309768-EDFD3C47-DB9F-42FE-993C-16BDD05AE0B1Q24337070-0D290A96-FFE7-4747-86ED-4AC71CDEC12CQ24557088-29A41659-B90D-47AC-9253-723FF2CAB10DQ24632895-7CB46BBB-0C6D-4229-92C8-93D7F734A6DCQ24657393-F6566F03-6A1F-457D-A3C4-473EC5E98708Q24672429-F6C051F8-CB20-4A4B-8EEE-F9405587FF79Q24685393-C992C574-4A13-4998-A881-22E15C0A6874Q24813627-4B156887-70AB-4211-AACA-88BE144A5BEFQ27007789-177B5EC8-17E0-4E87-A041-0B6C6259EFFEQ27687681-4D44C0A2-1099-44D4-B58A-E2BF17554024Q27852024-98C8B3E3-E259-45FA-8408-0827895A2188Q28119116-242877D7-4544-47D9-9CC3-2632CB101C3CQ28251097-38432B55-5BAE-43E7-9F94-1D66DC0FC5DFQ28254998-D71BE50E-1F7F-4DAC-9E88-435ABF26B743Q28270490-7B063252-8383-4EAB-A822-936E335BE3F4Q28271388-0CBF0CB4-1223-4ECE-B93D-83F07B6BFD45Q28273310-C0450775-39E3-4968-BF51-8DEA10953188Q28304891-124668A7-C549-4C87-AC73-451705468FE4Q28482848-3EACBF7B-176C-4A17-AFB3-C35D9B79D13EQ28550645-D85F9A54-6989-44D6-A1B6-5C5AE25A1BD0Q28568099-202B06A9-E7FB-4635-95D3-B31A4F048668Q28821664-11A1ABD6-0E9A-4520-A509-2038296AC1AEQ30412564-B81B9FFC-052D-4064-BBC8-EEC7E7841F2BQ30480773-C0093EAF-EFC1-46E1-A5AB-34E3CEC07EE3Q30493310-D105EB43-63DA-4CA3-8AF3-3444E0D64F19Q33324386-E070EE85-7660-4E50-8A71-A04CE6C7B5AFQ33384289-94F729B2-5FA1-4237-B45B-1C61BCD391DEQ33569159-95B03AFA-0088-42AD-80F7-91CB7B00294DQ33578641-65465250-B178-4517-88E9-993395DEB70FQ33582615-4BDEAAC0-E1B7-4718-A7D9-54FA46CACCC0Q33607950-72C2014E-CCFD-4F8E-BB5D-6970E15C3FEDQ33608728-389DE32E-FB59-49B9-81B7-14CAC6105DD8Q33612060-571F6A40-B4F4-4B7E-97DF-7C8B731D0457Q33615054-B9108F90-6BDE-4894-B937-87647BF1058EQ33676302-D14D9BA5-B6FE-4C8F-B781-B2FA18FF2FF4Q33701396-EC625A0E-B921-4C9F-B3E0-88D611B2CC32Q33729031-5FDA0802-2619-406E-9240-F33C0AAFC40FQ33742688-41A4661D-51EF-4BFF-B0E1-6E43F3647203Q33780217-AB23431A-CEC6-4A47-A6FF-7BA8DF1B293F
P2860
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
description
article
@en
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2004
@uk
name
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@en
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@nl
type
label
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@en
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@nl
prefLabel
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@en
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@nl
P2093
P50
P1433
P1476
High tumor incidence and activ ...... ice define AIB1 as an oncogene
@en
P2093
Francisca Vazquez
Maria I. Torres-Arzayus
Roderick Bronson
William R. Sellers
P304
P356
10.1016/J.CCR.2004.06.027
P577
2004-09-01T00:00:00Z