C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer? - Wikidata - wikimedia - TriplyDB

C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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im August 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 23 July 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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ACSMEDCHEMLETT.8B00314

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ACS Medicinal Chemistry Letters

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C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?

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Daniel Rauh

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Tobias Grabe

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Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.

Structural pharmacological studies on EGFR T790M/C797S.

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.

Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.

Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.

Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK

Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry.

Structural insights into drug development strategy targeting EGFR T790M/C797S.

Discovery of EGF Receptor Inhibitors That Are Selective for the d746-750/T790M/C797S Mutant through Structure-Based de Novo Design.

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779-782

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scholarly article

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10.1021/ACSMEDCHEMLETT.8B00314

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8

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9

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2018-07-23T00:00:00Z

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30128066

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6088362

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