Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress
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Cardiac regulation by phosphoinositide 3-kinases and PTENPhosphoinositide 3-kinase: friend and foe in cardiovascular diseasePTEN modulators: a patent reviewBeta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic miceRegulation of phosphatase and tensin homolog on chromosome 10 in response to hypoxia.CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway.Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy.Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagyRhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injuryEnhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunctionPanhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy.The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy.Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway.MEF2D deficiency in neonatal cardiomyocytes triggers cell cycle re-entry and programmed cell death in vitro.Myocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN/Akt signal pathway.Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation.Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription.Myocardial AKT: the omnipresent nexus.Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis.Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway.Cardiotoxicity associated with targeting kinase pathways in cancer.Focal adhesion signaling in heart failureAstrocyte Resilience to Oxidative Stress Induced by Insulin-like Growth Factor I (IGF-I) Involves Preserved AKT (Protein Kinase B) Activity.The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization.Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction.Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src.Protein tyrosine phosphatases in cardiac physiology and pathophysiology.Myocardial perfusion MRI shows impaired perfusion of the mouse hypertrophic left ventricle.Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases
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Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress
description
article
@en
im Januar 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2008
@uk
name
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
@en
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
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type
label
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
@en
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
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prefLabel
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
@en
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
@nl
P2093
P356
P1476
Loss of PTEN attenuates the de ...... sponse to biomechanical stress
@en
P2093
Fayez Dawood
Gavin Y Oudit
James W Scholey
Joyce Zhou
Michael A Crackower
Peter H Backx
Peter P Liu
Qiao C Liu
Zamaneh Kassiri
P304
P356
10.1093/CVR/CVN041
P577
2008-02-15T00:00:00Z