about
Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8(+) T cell responses.Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model.The changing shape of vaccination: improving immune responses through geometrical variations of a microdevice for immunizationInactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses.Potent response of QS-21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing.Corrigendum: The changing shape of vaccination: improving immune responses through geometrical variations of a microdevice for immunization.High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses.Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers.Induction of potent CD8⁺ T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely packed microprojection arrays.Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles.Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4+CD25+ T cellsImproving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilizationDry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skinSafety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arraysTargeted, Needle-Free Vaccinations in Skin using Multilayered, Densely-Packed Dissolving Microprojection ArraysThe effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccineNanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responsesRapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skinSecondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidityTLR7 stimulation augments T effector-mediated rejection of skin expressing neo-self antigen in keratinocytesFunctional memory CD8+ T cells can be generated in vivo without evident T helpHuman growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejectionSafety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch: Results from a randomized, controlled phase I clinical trialMicroprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Germain J.P. Fernando
@ast
Germain J.P. Fernando
@en
Germain J.P. Fernando
@es
Germain J.P. Fernando
@nl
type
label
Germain J.P. Fernando
@ast
Germain J.P. Fernando
@en
Germain J.P. Fernando
@es
Germain J.P. Fernando
@nl
prefLabel
Germain J.P. Fernando
@ast
Germain J.P. Fernando
@en
Germain J.P. Fernando
@es
Germain J.P. Fernando
@nl
P106
P31
P496
0000-0003-3260-0548