Inhibition of Chaperone Activity Is a Shared Property of Several Cu,Zn-Superoxide Dismutase Mutants That Cause Amyotrophic Lateral Sclerosis
about
A revisited folding reporter for quantitative assay of protein misfolding and aggregation in mammalian cells.Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival.Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALSProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation.A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivoEffect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: implication of a free radical hypothesisPosttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.Autophagy and neurodegenerative disorders.2-Deoxyglucose induces cell cycle arrest and apoptosisin colorectal cancer cells independent of its glycolysis inhibition.Mutant SOD1 detoxification mechanisms in intact single cells.SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity.Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.
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P2860
Inhibition of Chaperone Activity Is a Shared Property of Several Cu,Zn-Superoxide Dismutase Mutants That Cause Amyotrophic Lateral Sclerosis
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im März 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2005
@uk
name
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@en
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@nl
type
label
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@en
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@nl
prefLabel
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@en
Inhibition of Chaperone Activi ...... Amyotrophic Lateral Sclerosis
@nl
P2093
P2860
P356
P1476
Inhibition of chaperone activi ...... amyotrophic lateral sclerosis
@en
P2093
Cheolwha Jung
Cynthia M J Higgins
Hemachand Tummala
Lawrence J Hayward
Zuoshang Xu
P2860
P304
17725-17731
P356
10.1074/JBC.M501705200
P407
P577
2005-03-07T00:00:00Z