Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I
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The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrilsAmyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosisAmyloidogenic propensity of a natural variant of human apolipoprotein A-I: stability and interaction with ligandsThe crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment.Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions.Immunochemical Approach for Monitoring of Structural Transition of ApoA-I upon HDL Formation Using Novel Monoclonal AntibodiesConformational and aggregation properties of the 1-93 fragment of apolipoprotein A-I.Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I.Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.A new prion disease: relationship with central and peripheral amyloidoses.Apolipoprotein A-I: the dual face of a protein.Insights into the fate of the N-terminal amyloidogenic polypeptide of ApoA-I in cultured target cellsBenzalkonium chloride accelerates the formation of the amyloid fibrils of corneal dystrophy-associated peptides.sw ApoMb Amyloid Aggregation under Nondenaturing Conditions: The Role of Native Structure Stability.Heparin promotes fibril formation by the N-terminal fragment of amyloidogenic apolipoprotein A-I.Insights into human phosphoglycerate kinase 1 deficiency as a conformational disease from biochemical, biophysical, and in vitro expression analyses.Apolipoprotein A-I amyloidogenic variant L174S, expressed and isolated from stably transfected mammalian cells, is associated with fatty acids.Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin
P2860
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P2860
Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I
description
article
@en
im April 2011 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2011
@uk
name
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@en
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@nl
type
label
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@en
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@nl
prefLabel
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@en
Effects of the Known Pathogeni ...... Peptide of Apolipoprotein A-I
@nl
P2093
P50
P1476
Effects of the known pathogeni ...... peptide of apolipoprotein A-I
@en
P2093
Angela Arciello
Annalisa Relini
Christopher M Dobson
Daniela Nichino
Daria M Monti
Fulvio Guglielmi
Monica Stoppini
Palma Mangione
Paul Robustelli
Renata Piccoli
P304
P356
10.1016/J.JMB.2011.01.044
P407
P50
P577
2011-02-04T00:00:00Z