Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes
about
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferationDecreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionTCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cellsPharmacogenetic studies update in type 2 diabetes mellitusThe association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysisGenetically modified mouse models for the study of nonalcoholic fatty liver diseaseAssociation of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysisDeletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetesTCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liverPharmacogenomics in type 2 diabetes: oral antidiabetic drugs.Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS.Islet specific Wnt activation in human type II diabetes.TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.Effects of the diabetes linked TCF7L2 polymorphism in a representative older populationTCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French populationSecretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.The TCF7L2 locus and type 1 diabetesGenome-wide association with diabetes-related traits in the Framingham Heart StudyCommon variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association dataAssociation between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysisAlternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC StudyGenetics of type 2 diabetes: insights into the pathogenesis and its clinical application.Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndromeGene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes.Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansThe T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta-analysis.Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.A flexible likelihood framework for detecting associations with secondary phenotypes in genetic studies using selected samples: application to sequence dataPharmacogenetics of Anti-Diabetes Drugs.A powerful approach to sub-phenotype analysis in population-based genetic association studies
P2860
Q24307581-3A6BD4B6-6AD9-4D25-9C39-605245AB72F3Q24318496-37F9C90F-9EE4-4378-8C6C-8991938E0E5FQ24321979-515A6E3F-F8CD-4DCF-ABE8-76E2722AB0C2Q26739350-F4E05B6C-C186-4922-8E55-AF2D464A15DBQ26801544-4785FBBD-6800-4260-98C4-44F8E4BC6F90Q26865248-02999A6F-91C8-4D19-A2F9-70089CE00B29Q26995366-20C1BACB-1058-4CC5-A52D-D171B5269613Q27339473-4E633AAE-A146-4272-AD0E-3A85F94F2953Q28589957-16336456-C223-45D2-A8D0-E101F56BE9A8Q30248914-E205CF50-8A2B-4665-914A-F9474CBE7F21Q30423757-8448A220-5407-4B8D-808B-1EE08A2F1930Q30485515-73B2849A-5834-4ADA-92AB-4B1D8133649EQ30847258-79BB7146-ECE0-45E0-95CF-43781F8A41E4Q33267201-E9686125-6595-4088-83B4-474A46549619Q33288924-0E36548D-310F-4D8B-B259-2154FE2080C5Q33290257-135B7602-99F1-481D-85CD-6A1E0A2756B3Q33293418-2E011393-5DE6-4A5D-8B53-DC2E49CA1819Q33300811-EF301A05-54C6-4DF4-B363-C52D1FE87E13Q33320767-D727D4FE-F76C-4E94-A87E-6AEA23C9E42AQ33337238-2D80490D-79B8-48AD-A671-87362E5CE0A6Q33355188-9FF14EBB-308D-400B-A01E-22B797612D0FQ33389614-6A4ECA61-DB9B-40C4-BC9F-63BF48911767Q33389729-9B83032C-89FA-4ACF-ADF9-FF6D089C41D8Q33410679-B38F0D91-5288-48DA-BDD4-4549910BA438Q33507522-1B9CAAFE-989B-4267-A19D-FCCE52785283Q33525709-574F126E-C44F-4DAF-8530-DBC67A454C38Q33531795-82F353AA-7173-4F5A-BEC6-456B6569AD50Q33579567-0375D8FE-E069-42B2-BBE3-2960DB21705FQ33593963-BC3C8B31-F529-4907-9342-8E26ECB62492Q33679358-8DC6EA6E-B8BD-4286-B718-D1D04BA959A3Q33688627-B74ED4F6-C3A3-4869-A9CB-5D93A1D942EEQ33738665-1B448958-4542-4EC6-A7D0-F03ECC821113Q33750703-ACDBDC99-B8EE-4B1B-8735-02073C701D39Q33771570-B31BFFE6-3E0C-4325-BA07-019B7395A059Q33829240-FB3A5BBE-446A-4650-BDA8-3DCC8BEB5014Q33871333-E96A2DA5-D9B2-4D33-A55F-2C58A317FAF9Q34078964-BA123409-4DBE-4FBC-8242-B54BE8408D97Q34100213-3166B9DE-B04B-4BC9-88FB-04585E6CCFBCQ34181995-2BD6BF40-82FD-412D-8F21-5FB315F749CCQ34243000-366EC00B-9EEA-4757-B7C4-943110C685AA
P2860
Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes
description
article
@en
im Oktober 2006 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2006
@uk
name
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@en
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@nl
type
label
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@en
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@nl
prefLabel
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@en
Transcription Factor TCF7L2 Ge ...... sociation With Type 2 Diabetes
@nl
P2093
P50
P356
P1433
P1476
Transcription factor TCF7L2 ge ...... sociation with type 2 diabetes
@en
P2093
Beverley Balkau
Chantal Samson
Christian Dina
David Meyre
Gema Frühbeck
Guillaume Charpentier
Stéphane Cauchi
Volodymyr Stetsyuk
P304
P356
10.2337/DB06-0474
P407
P577
2006-10-01T00:00:00Z