PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

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http://www.wikidata.org/entity/Q57260217
Leptin applications in 2015: what have we learned about leptin and obesity?Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.Protein-polymer conjugation-moving beyond PEGylation.Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesityHalf-life extended biotherapeutics.Materials and methods for delivery of biological drugs.Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation.Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation.The polypeptide biophysics of proline/alanine-rich sequences (PAS): Recombinant biopolymers with PEG-like properties.Development of a novel nano-sized anti-VEGFA nanobody with enhanced physicochemical and pharmacokinetic properties.Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity.Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.PASylation technology improves recombinant interferon-β1b solubility, stability, and biological activity.A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery
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PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

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http://www.wikidata.org/entity/Q57260217
description
im April 2015 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2015
@uk
name
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@en
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@nl
type
label
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@en
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@nl
prefLabel
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@en
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
PASylation of Murine Leptin Le ...... and Enhanced in Vivo Efficacy
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698