Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis
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Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actinCytotoxic granule secretion by lymphocytes and its link to immune homeostasisCrystal structure of the dimerization domain of human filamin AGranzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization.Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Rho GTPase signalling pathways in the morphological changes associated with apoptosis.The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domainThe dual role of filamin A in cancer: can't live with (too much of) it, can't live without it.Peripheral blood mononuclear cell proteome changes in patients with myelodysplastic syndromeHuman and murine granzyme B exhibit divergent substrate preferencesThe actin cytoskeleton as a sensor and mediator of apoptosisApoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells.Mechanisms of granule-dependent killing.Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastasesFilamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth.Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response.Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells.A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.Controversies in granzyme biology.Degradation of filamin induces contraction of vascular smooth muscle cells in type-I collagen matrix honeycombs.Filamin A: Insights into its Exact Role in Cancers.Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cells.Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280.New insights to the MLL recombinome of acute leukemias.FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression.The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches.In-frame deletion in FLNA causing familial periventricular heterotopia with skeletal dysplasia in males.Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
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Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2000
@uk
name
Filamin (280-kDa Actin-binding ...... se Granzyme B during Apoptosis
@en
Filamin
@nl
type
label
Filamin (280-kDa Actin-binding ...... se Granzyme B during Apoptosis
@en
Filamin
@nl
prefLabel
Filamin (280-kDa Actin-binding ...... se Granzyme B during Apoptosis
@en
Filamin
@nl
P2860
P356
P1476
Filamin (280-kDa Actin-binding ...... se Granzyme B during Apoptosis
@en
P2093
David A. Jans
Kylie A. Browne
P2860
P304
39262-39266
P356
10.1074/JBC.C000622200
P407
P577
2000-10-24T00:00:00Z