Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
about
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive valueIntegrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locusGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsA genome-wide study reveals copy number variants exclusive to childhood obesity casesSignals of recent positive selection in a worldwide sample of human populationsIs genetic testing useful to predict type 2 diabetes?Transcriptional and epigenetic regulation in human isletsEarly Neolithic genomes from the eastern Fertile CrescentGenetic determinants of hair, eye and skin pigmentation in EuropeansPolymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic RGene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING StudiesTCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liverHuman-specific derived alleles of CD33 and other genes protect against postreproductive cognitive declineEvolutionary adaptations to dietary changesRevisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetesMethodological challenges of genome-wide association analysis in AfricaSelection for adaptation to dietary shifts: towards sustainable breeding of carnivorous fishThe emergence of human-evolutionary medical genomicsTCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention programAfrican genetic diversity: implications for human demographic history, modern human origins, and complex disease mappingNatural selection on genes that underlie human disease susceptibilityGenome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.A variant in CDKAL1 influences insulin response and risk of type 2 diabetesPharmacogenomics in type 2 diabetes: oral antidiabetic drugs.Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetesIn search of causal variants: refining disease association signals using cross-population contrasts.Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseasesTCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French populationThe TCF7L2 locus and type 1 diabetesAdaptations to climate in candidate genes for common metabolic disordersCommon variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.Worldwide population differentiation at disease-associated SNPs.Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysisHaplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
P2860
Q21092217-E5BB1923-3A7A-4697-8832-73174EA1DD64Q21136048-6C59DD51-BABF-4476-8B7C-7C6022790AFAQ24550675-7F9BB2A8-96CC-4179-A33D-E228CF1B3D5CQ24607677-C3574E7A-3397-40B8-B192-6386E7B467D6Q24651949-7BBC51E3-B607-4FDE-A876-D7DA2C2B97B9Q26859442-AD1BC9CE-0FFA-481D-8E75-FF876595476EQ27001134-F77BFE9F-75B5-419C-A2E7-15AECE4E1866Q27480266-C8465E6B-3686-4688-A305-5AB05672A8F3Q28254206-BBEBE94B-7890-4FA9-9460-56C305D1AB26Q28354290-9D2956B4-1003-429F-A72A-F76B07A645FFQ28397345-96B8872E-2667-47FF-A6EA-A5E7BF85F780Q28589957-E0D7ACEA-3A40-465A-8D66-9A5486BE6A50Q28602637-20E0398F-2814-42D3-A304-BDB3AA059746Q28655778-9FDCD413-F960-4A32-A7A5-F5C0EDCBD851Q28658911-051A7FD5-B5AF-4B3E-9D00-38C03B43B5AFQ28681049-77DC4C37-4A79-4920-A701-6758B89B686CQ28727390-3B9088BF-A483-417E-8CFE-DA563DF151A3Q28729955-2B325B89-D7AD-4249-BF8F-CBFDE6BD13C7Q28742128-CD57E253-E919-4066-BE6F-2DDD270E10D3Q28748891-93DBB3E8-9EFF-4407-AC00-81DAEBCA6E64Q28757653-A05DE11F-18B3-42DA-AAD9-4284FA0BF5D7Q28943291-7EE7ED3D-8BC7-487C-9DD4-DAF9F06CDFDDQ29614878-32D16F50-A9B3-463B-9DA3-6C5299A40F8EQ30248914-88D02DC3-27E4-4765-A628-3FF3BA1476ABQ30368908-9ABF550D-5305-4F4A-9493-EAE836793DA9Q30437463-F1129F40-8CFF-4104-8173-2D19B10866A8Q30844915-66ED037C-B090-4F53-90FD-0EE247BBD3D0Q30847502-2BF6DBC3-9355-4740-AAE0-8B5E05ED0A42Q30914210-549D8C49-B839-4362-865B-7A8C229F8C46Q33288924-25C08A35-B65E-4CE4-821F-0B32E3C42ED8Q33293418-5F68E4F3-D941-4635-89A3-08CFCCFC298EQ33320199-DF10FF02-AE70-4192-8E28-8B8F75F96163Q33320767-31C0C581-E84F-45B0-96C4-C569D0DE824BQ33323357-B3905697-11BD-4456-9268-AF8612FF8705Q33340690-D5CF8792-9244-480C-97B8-0ABD933D091FQ33355142-4178BC24-CA87-4BF1-8328-854F01EAC773Q33389614-C396F5AB-C2E0-498D-B2F2-484CE25CBD29Q33410679-CED24F0F-F35B-4BCE-A8CF-43F82E6ADD2EQ33414409-0440D0D0-1CAC-45DE-B3D3-F77696CE1AFAQ33483639-6E40C4E7-0B63-4598-945A-7A4EDD52D647
P2860
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
description
article
@en
im Januar 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2007
@uk
name
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@en
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@nl
type
label
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@en
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@nl
prefLabel
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@en
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@nl
P2093
P2860
P50
P356
P1433
P1476
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
@en
P2093
Agnar Helgason
Anke Hinney
Ayo Doumatey
Claus Christiansen
Daniel J Rader
Gitte Andersen
Guanjie Chen
Gunnar Sigurdsson
Helmut Schäfer
Inga Reynisdottir
P2860
P2888
P304
P356
10.1038/NG1960
P407
P50
P577
2007-01-07T00:00:00Z