Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution - Wikidata - wikimedia - TriplyDB

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

http://www.wikidata.org/entity/Q57278407

about

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls A genome-wide study reveals copy number variants exclusive to childhood obesity cases Signals of recent positive selection in a worldwide sample of human populations Is genetic testing useful to predict type 2 diabetes?Transcriptional and epigenetic regulation in human islets Early Neolithic genomes from the eastern Fertile Crescent Genetic determinants of hair, eye and skin pigmentation in Europeans Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic R Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline Evolutionary adaptations to dietary changes Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes Methodological challenges of genome-wide association analysis in Africa Selection for adaptation to dietary shifts: towards sustainable breeding of carnivorous fish The emergence of human-evolutionary medical genomics TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping Natural selection on genes that underlie human disease susceptibility Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs.Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes In search of causal variants: refining disease association signals using cross-population contrasts.Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population The TCF7L2 locus and type 1 diabetes Adaptations to climate in candidate genes for common metabolic disorders Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.Worldwide population differentiation at disease-associated SNPs.Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies

P2860

Q21092217-E5BB1923-3A7A-4697-8832-73174EA1DD64 Q21136048-6C59DD51-BABF-4476-8B7C-7C6022790AFA Q24550675-7F9BB2A8-96CC-4179-A33D-E228CF1B3D5C Q24607677-C3574E7A-3397-40B8-B192-6386E7B467D6 Q24651949-7BBC51E3-B607-4FDE-A876-D7DA2C2B97B9 Q26859442-AD1BC9CE-0FFA-481D-8E75-FF876595476E Q27001134-F77BFE9F-75B5-419C-A2E7-15AECE4E1866 Q27480266-C8465E6B-3686-4688-A305-5AB05672A8F3 Q28254206-BBEBE94B-7890-4FA9-9460-56C305D1AB26 Q28354290-9D2956B4-1003-429F-A72A-F76B07A645FF Q28397345-96B8872E-2667-47FF-A6EA-A5E7BF85F780 Q28589957-E0D7ACEA-3A40-465A-8D66-9A5486BE6A50 Q28602637-20E0398F-2814-42D3-A304-BDB3AA059746 Q28655778-9FDCD413-F960-4A32-A7A5-F5C0EDCBD851 Q28658911-051A7FD5-B5AF-4B3E-9D00-38C03B43B5AF Q28681049-77DC4C37-4A79-4920-A701-6758B89B686C Q28727390-3B9088BF-A483-417E-8CFE-DA563DF151A3 Q28729955-2B325B89-D7AD-4249-BF8F-CBFDE6BD13C7 Q28742128-CD57E253-E919-4066-BE6F-2DDD270E10D3 Q28748891-93DBB3E8-9EFF-4407-AC00-81DAEBCA6E64 Q28757653-A05DE11F-18B3-42DA-AAD9-4284FA0BF5D7 Q28943291-7EE7ED3D-8BC7-487C-9DD4-DAF9F06CDFDD Q29614878-32D16F50-A9B3-463B-9DA3-6C5299A40F8E Q30248914-88D02DC3-27E4-4765-A628-3FF3BA1476AB Q30368908-9ABF550D-5305-4F4A-9493-EAE836793DA9 Q30437463-F1129F40-8CFF-4104-8173-2D19B10866A8 Q30844915-66ED037C-B090-4F53-90FD-0EE247BBD3D0 Q30847502-2BF6DBC3-9355-4740-AAE0-8B5E05ED0A42 Q30914210-549D8C49-B839-4362-865B-7A8C229F8C46 Q33288924-25C08A35-B65E-4CE4-821F-0B32E3C42ED8 Q33293418-5F68E4F3-D941-4635-89A3-08CFCCFC298E Q33320199-DF10FF02-AE70-4192-8E28-8B8F75F96163 Q33320767-31C0C581-E84F-45B0-96C4-C569D0DE824B Q33323357-B3905697-11BD-4456-9268-AF8612FF8705 Q33340690-D5CF8792-9244-480C-97B8-0ABD933D091F Q33355142-4178BC24-CA87-4BF1-8328-854F01EAC773 Q33389614-C396F5AB-C2E0-498D-B2F2-484CE25CBD29 Q33410679-CED24F0F-F35B-4BCE-A8CF-43F82E6ADD2E Q33414409-0440D0D0-1CAC-45DE-B3D3-F77696CE1AFA Q33483639-6E40C4E7-0B63-4598-945A-7A4EDD52D647

P2860

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

http://www.wikidata.org/entity/Q57278407

description

article

@en

im Januar 2007 veröffentlichter wissenschaftlicher Artikel

@de

wetenschappelijk artikel

@nl

наукова стаття, опублікована в січні 2007

@uk

name

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@en

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@nl

type

label

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@en

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@nl

prefLabel

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@en

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@nl

P1433

Q57278407-3C704987-D05E-4D8E-8988-B897CD358380

P1476

Q57278407-45AB9393-0F5A-471A-A43A-3658130DE631

P2093

Q57278407-0F1F8E8A-948A-4B2B-8042-EF5F5B152597

Q57278407-1AF16B8D-6A9D-4C89-805A-C7C0F73948B8

Q57278407-23CAD6A9-5518-456F-9BDD-58DDEFDB1708

Q57278407-31C6CBE5-784C-4D89-A188-BB993D3756F0

Q57278407-5B74DFEF-9483-49B8-A7CC-7E21A63120C3

Q57278407-6A6374D7-A4DF-47CB-9715-9A7116385564

Q57278407-75DD9F2B-063A-4DB5-AA6C-368DC926CAC0

Q57278407-84C42B34-987B-4537-8AA2-F94373863838

Q57278407-8905E0B5-B1D0-460D-8674-270F6E5F2C4A

Q57278407-9DA7302A-60B6-477D-ADC1-9743D6E90B95

P2860

Q57278407-1152DB75-DE11-4FDC-99B5-756A340A1542

Q57278407-1CBEEDD2-8795-470E-A650-090029C6E33C

Q57278407-2B786633-08F0-47C1-91EB-E390B94F0787

Q57278407-2E7A4793-3F14-4E45-847C-1E2F4CD08239

Q57278407-3920A4F8-F867-448E-8CE5-8E893D4E4E1F

Q57278407-42DEFABD-FEE0-4F92-84D9-41BE2BFD79CD

Q57278407-4E1CD08A-8B93-4653-B9A2-1C53D7BEA83F

Q57278407-695E6FD7-03FA-4466-B91C-991E5753B79F

Q57278407-7885BE92-CC02-433E-B466-6D97267D6619

Q57278407-7C0CC805-683B-4A66-9B66-56D4C6D8FF6C

P2888

Q57278407-E979E157-3F56-4265-8D59-5C6492D16C64

P304

Q57278407-10883235-79FA-444B-A3C9-5D109AC9CE02

P31

Q57278407-2EAFEC69-A0D4-425F-82AC-B191262719D6

P356

Q57278407-5C1990FD-0638-4036-BACC-14029713573D

P407

Q57278407-2A347BFE-8F58-4665-AB3A-28A3C030A62C

P433

Q57278407-B418941C-A9C3-45E5-B06B-B829E111CA4A

P478

Q57278407-10357E51-FE12-45B6-8401-794C073C4E56

P50

Q57278407-0F042D15-817C-42E4-ACD0-969CD7FFD225

Q57278407-3A72D8C5-4B94-40AB-8163-6A256897AB5D

Q57278407-6A5F799B-62AE-4A7E-BEB7-6679D2C7CCDC

Q57278407-B17E1642-383A-42B5-9874-5EC8015A2A5C

Q57278407-B5D3AFD8-D964-475D-8E97-42B50987CBAC

Q57278407-B61F40D4-536A-4933-B976-EA0E976563C8

Q57278407-E0DA3EE7-96EE-4468-8A2A-B04A608269F4

Q57278407-E3708EFA-BCDD-4A5F-9400-5E7EA317A575

Q57278407-E94491BD-C09A-4B62-8AA0-093C4BE69542

Q57278407-F9E9B5D1-66DE-47AF-A93E-9F3EBC55CC87

P577

Q57278407-AE40F84A-9D19-4D90-95A7-9264DC2B1FC4

P698

Q57278407-ECA83FD3-831B-49DA-A6D6-28E23B3369CA

P921

Q57278407-09D233B9-1274-4B6B-9255-8D1AE8BDEA9A

P356

P1433

Nature Genetics

P1476

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

@en

P2093

Agnar Helgason

http://www.w3.org/2001/XMLSchema#string

Anke Hinney

http://www.w3.org/2001/XMLSchema#string

Ayo Doumatey

http://www.w3.org/2001/XMLSchema#string

Claus Christiansen

http://www.w3.org/2001/XMLSchema#string

Daniel J Rader

http://www.w3.org/2001/XMLSchema#string

Gitte Andersen

http://www.w3.org/2001/XMLSchema#string

Guanjie Chen

http://www.w3.org/2001/XMLSchema#string

Gunnar Sigurdsson

http://www.w3.org/2001/XMLSchema#string

Helmut Schäfer

http://www.w3.org/2001/XMLSchema#string

Inga Reynisdottir

http://www.w3.org/2001/XMLSchema#string

P2860

A map of recent positive selection in the human genome

Detecting recent positive selection in the human genome from haplotype structure

Genetic structure in four West African population groups

Median-joining networks for inferring intraspecific phylogenies

A high-resolution recombination map of the human genome

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Role of neuropeptides in appetite regulation and obesity--a review.

In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study.

How reliable are empirical genomic scans for selective sweeps?

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

P2888

P304

218-225

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG1960

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

39

http://www.w3.org/2001/XMLSchema#string

P50

Gudmar Thorleifsson

Unnur Þorsteinsdóttir

Oluf Borbye Pedersen

Rafn Benediktsson

Johannes Hebebrand

Adebowale Adeyemo

Muredach P. Reilly

P577

2007-01-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17206141

http://www.w3.org/2001/XMLSchema#string

P921

type-2 diabetes