about
PI3Kα inhibition reduces obesity in miceDesign and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen species.Pten positively regulates brown adipose function, energy expenditure, and longevity.Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damageA cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.Identification of novel PI3K inhibitors through a scaffold hopping strategy.Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonismCascade Reaction of 6-Deoxy-6-iodohexopyranosides Promoted by Samarium Diiodide: A New Ring Contraction of Carbohydrate DerivativesPreclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancerThe targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN statusMultiple cancer pathways regulate telomere protectionDiscovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitorsAnti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastomaAnti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma
P50
Q28818545-C7B5BACC-E5B7-42C3-804E-6587526E3887Q33496497-3027C751-EB8B-41E5-A871-FA3C342CC571Q34260134-932CA423-D6DC-410B-8700-7300BAF1A6C4Q35904248-A8E0B103-0ED9-42FD-87C5-0348818D5D87Q36908567-B1492AF4-88BE-48AB-BFE0-FBE20651C282Q38839701-3106AA74-4A4D-4650-9A0A-A4A268A77FF0Q39310774-AAF88306-003D-4CC2-91BD-3FD1F43C571BQ39343270-5E25BE00-F9AA-45B0-B533-F87B9025FB75Q44520564-E6948913-AD8D-4B63-AE12-E083B2768235Q44882691-79EDF3D0-FE0C-4E61-97A8-6E31AAE79DB7Q46383120-3CE789E5-685B-4C2C-9C5A-E4D35ABB5ED0Q47404698-97633348-49B6-4756-89A9-6E58C8DE2BF7Q47669882-284A846D-9201-4BF4-AF9E-C807F9BBF74CQ51766198-3EA64569-140D-427B-8E0C-DC24C4E44E53Q53251314-6C8901E4-D2B3-47D3-AA39-AB5AB41E91E1Q54281359-4E983FD4-6A92-46C9-A1E5-F1EFE651D200Q54516102-89C82B5D-7E23-40F3-B21E-D420677B8C09Q58136475-11C0C885-94DD-4018-849D-44B934F01160Q74824019-1A09F370-25FF-4B20-AB3F-D5ED76464795Q89637594-4739BFEC-6729-4FB6-AF32-279883255255Q91525301-F497C51F-345D-4067-BA5B-6B68EFEFFB7BQ91627316-B7BA58BF-9643-411F-A583-F8CF88C2E41EQ91893455-FBF864B6-1A36-40E0-B820-7E5A7E146CFBQ91918375-041C150D-461B-438F-B5DA-7ADC6D50BD02Q92509850-A1468401-98A8-48DE-8B94-30C65E5C4B8A
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sonia Martinez
@ast
Sonia Martinez
@en
Sonia Martinez
@es
Sonia Martinez
@nl
type
label
Sonia Martinez
@ast
Sonia Martinez
@en
Sonia Martinez
@es
Sonia Martinez
@nl
prefLabel
Sonia Martinez
@ast
Sonia Martinez
@en
Sonia Martinez
@es
Sonia Martinez
@nl
P106
P31
P496
0000-0003-2230-7794