about
Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocationEnergy disruptors: rising stars in anticancer therapy?Implication of inflammatory signaling pathways in obesity-induced insulin resistanceHyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytesPositive and negative regulation of insulin signaling through IRS-1 phosphorylationThe interaction between the adaptor protein APS and Enigma is involved in actin organisationTpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant miceMetformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells.Adipose tissue microRNAs as regulators of CCL2 production in human obesitySestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced deathInhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4.Hypoxia decreases insulin signaling pathways in adipocytesTransfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism.Metformin and cancer therapy.Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages.Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.Implication of REDD1 in the activation of inflammatory pathways.Isolation and characterization of a T lymphocyte mutant defective in the protein kinase C signal transduction pathway.Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.Polymyxin B selectively inhibits insulin effects on transport in isolated muscle.Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes.Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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type
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
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Jean-François Tanti
@nl
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P106
P214
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0000-0003-1782-1318
P735
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viaf-223767710