A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus
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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociIntegrin-based therapeutics: biological basis, clinical use and new drugsGenes associated with SLE are targets of recent positive selectionClinical perspectives on lupus genetics: advances and opportunitiesDisease mechanisms in rheumatology--tools and pathways: defining functional genetic variants in autoimmune diseasesAdvances in lupus geneticsRecent advances in the genetics of autoimmune diseaseEmerging therapies for systemic lupus erythematosus--focus on targeting interferon-alphaMeta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in AsiansGWAS identifies novel SLE susceptibility genes and explains the association of the HLA regionA genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in JapaneseGenome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.Seven newly identified loci for autoimmune thyroid disease.ENDEAVOUR update: a web resource for gene prioritization in multiple speciesReplication of recently identified systemic lupus erythematosus genetic associations: a case-control study.Gene expression profiles in a rabbit model of systemic lupus erythematosus autoantibody productionMultiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.Gene-based meta-analysis of genome-wide association study data identifies independent single-nucleotide polymorphisms in ANXA6 as being associated with systemic lupus erythematosus in Asian populations.A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those withoutSolving the genetic puzzle of systemic lupus erythematosus.Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin.Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosusThe lupus family registry and repository.Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases.Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosusAntiviral immune responses: triggers of or triggered by autoimmunity?Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish populationFcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African AmericansPathways: Strategies for susceptibility genes in SLE.Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAMLack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus.ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.Recent advances in the genetics of systemic lupus erythematosus.Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.Recent findings on genetics of systemic autoimmune diseasesGenome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibilityFurther evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only studyIdentification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
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A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus
description
article
@en
im Januar 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2008
@uk
name
A nonsynonymous functional var ...... h systemic lupus erythematosus
@en
A nonsynonymous functional variant in integrin-αM
@nl
type
label
A nonsynonymous functional var ...... h systemic lupus erythematosus
@en
A nonsynonymous functional variant in integrin-αM
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prefLabel
A nonsynonymous functional var ...... h systemic lupus erythematosus
@en
A nonsynonymous functional variant in integrin-αM
@nl
P2093
P50
P356
P1433
P1476
A nonsynonymous functional var ...... h systemic lupus erythematosus
@en
P2093
Edward K Wakeland
Gary S Gilkeson
Joan T Merrill
Kenneth M Kaufman
Parvathi Viswanathan
Quan-Zhen Li
Rodger P McEver
Shizhong Han
Swapan K Nath
P2888
P304
P356
10.1038/NG.71
P407
P50
P577
2008-01-20T00:00:00Z