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Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus developmentT1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector functionRoles of transcriptional factor 7 in production of inflammatory factors for lung diseasesNovel mouse model reveals distinct activity-dependent and -independent contributions to synapse developmentKu70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombinationInterleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiationLate embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IVLearning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient miceMice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous systemBiosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient miceIncreased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitizationAbnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient miceICOS is essential for effective T-helper-cell responsesInvariant NKT cells sustain specific B cell responses and memory.Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesisClinical needs for hematopoietic growth factors: old and new.Specificity of signaling by hematopoietic cytokine receptors: instructive versus permissive effects.Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice.A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signalingThe protooncogene MYC can break B cell toleranceIL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.Type 1/Type 2 immunity in infectious diseases.Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice.Cytokine fingerprinting and hazard assessment of chemical respiratory allergy.Splenectomy and sepsis: the role of the spleen in the immune-mediated bacterial clearance.Synergetic cooperation of microRNAs with transcription factors in iPS cell generation.Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Processing of switch transcripts is required for targeting of antibody class switch recombination.Interleukin-4 and interleukin-13: their similarities and discrepancies.Cytokines and immunodeficiency diseases.Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis.Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells.Stochastic cytokine expression induces mixed T helper cell States.T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.Cytokine and chemokine responses underlying acute and chronic Trichuris muris infection.Calbindin D(9k) knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium level.Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell.The regulation and role of c-FLIP in human Th cell differentiationThe interleukin network and lymphoid development.Biology and therapeutic potential of the interleukin-4/interleukin-13 signaling pathway in asthma.
P2860
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P2860
description
article publié dans la revue scientifique Science
@fr
im November 1991 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 1991
@uk
name
Generation and analysis of interleukin-4 deficient mice
@en
Generation and analysis of interleukin-4 deficient mice
@nl
type
label
Generation and analysis of interleukin-4 deficient mice
@en
Generation and analysis of interleukin-4 deficient mice
@nl
prefLabel
Generation and analysis of interleukin-4 deficient mice
@en
Generation and analysis of interleukin-4 deficient mice
@nl
P356
P1433
P1476
Generation and analysis of interleukin-4 deficient mice
@en
P2093
P304
P356
10.1126/SCIENCE.1948049
P407
P577
1991-11-01T00:00:00Z