Endostatin Associates with Lipid Rafts and Induces Reorganization of the Actin Cytoskeleton via Down-regulation of RhoA Activity
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KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfateThe anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent mannerThe response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent.Matricryptins Network with Matricellular Receptors at the Surface of Endothelial and Tumor Cellsp190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migrationRho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemiaRegulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I.E-selectin is required for the antiangiogenic activity of endostatinEffects of receptor clustering on ligand dissociation kinetics: theory and simulations.Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation.Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.The clinical potential of antiangiogenic fragments of extracellular matrix proteinsEndorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.Low-molecular-weight heparins and angiogenesis.Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengersThe extracellular matrix and blood vessel formation: not just a scaffold.Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy.Anastellin, the angiostatic fibronectin peptide, is a selective inhibitor of lysophospholipid signaling.Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation.Molecular interplay between endostatin, integrins, and heparan sulfate.Endostatin specifically targets both tumor blood vessels and lymphatic vessels.Antiangiogenic and anticancer molecules in cartilage.Endostatin overexpression specifically in the lens and skin leads to cataract and ultrastructural alterations in basement membranes.Negative regulators of angiogenesis: important targets for treatment of exudative AMD.Modulation of the cellular cholesterol level affects shedding of the type XIII collagen ectodomain.The morphogenic properties of oligomeric endostatin are dependent on cell surface heparan sulfate.Endostatin therapy reveals a U-shaped curve for antitumor activity.Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment.An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells.Potential therapeutic implications of intracrine angiogenesis.Endostatin and anastellin inhibit distinct aspects of the angiogenic process.p190 RhoGTPase-activating protein links the β1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling.A Cellular Networking Model Involving Interactions Among Glycosyl-Phosphatidylinositol (GPI)-Anchored Plasma Membrane Arabinogalactan Proteins (AGPs), Microtubules and F-actin in Tobacco BY-2 Cells.Expression of VEGF and collagen XVIII in meningiomas: correlations with histopathological and MRI characteristics.TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention.Endostatin phenylalanines 31 and 34 define a receptor binding site.The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells.Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.
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Endostatin Associates with Lipid Rafts and Induces Reorganization of the Actin Cytoskeleton via Down-regulation of RhoA Activity
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2003
@uk
name
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@en
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@nl
type
label
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@en
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@nl
prefLabel
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@en
Endostatin Associates with Lip ...... wn-regulation of RhoA Activity
@nl
P2860
P356
P1476
Endostatin associates with lip ...... wn-regulation of RhoA activity
@en
P2093
Jorma Keski-Oja
P2860
P304
37895-37901
P356
10.1074/JBC.M303569200
P407
P577
2003-07-08T00:00:00Z