Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis
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Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesMolecular mechanisms of cellular cholesterol effluxThe interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipidsConversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytesA novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretionDisruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan.Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.Expression of human hepatic lipase negatively impacts apolipoprotein A-I production in primary hepatocytes from Lipc-null mice.Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol exportMultimarker screening of oxidative stress in aging.An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.Characteristics and functional relevance of apolipoprotein-A1 and cholesterol binding in mammary gland tissues and epithelial cellsABCA1 and nascent HDL biogenesisUp-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathwayNascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase.Regulation of ABCA1 functions by signaling pathwaysNascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL.Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomersCholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I.HDL, Atherosclerosis, and Emerging TherapiesABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDLABC transporters, atherosclerosis and inflammation.High-density lipoproteins and cardiovascular disease: 2010 update.Function and regulation of ABCA1--membrane meso-domain organization and reorganization.Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesisSodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation.ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments.PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.The β-subunit of ATP synthase is involved in cellular uptake and resecretion of apoA-I but does not control apoA-I-induced lipid efflux in adipocytesInteraction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I.An induction in hepatic HDL secretion associated with reduced ATPase expression.Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis.A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.Is ABCA1 a Lipid Transfer Protein?ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.
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Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis
description
article
@en
im Juli 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2007
@uk
name
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@en
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@nl
type
label
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@en
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@nl
prefLabel
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@en
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@nl
P2093
P2860
P1154
2-s2.0-35848942798
P1476
Identification of an ABCA1-dep ...... rrent models of HDL biogenesis
@en
P2093
Dana Nyholt
Dong-Young Donna Lee
Houssein Hajj Hassan
Iulia Iatan
Larbi Krimbou
Maxime Denis
P2860
P304
P356
10.1194/JLR.M700206-JLR200
P407
P577
2007-07-26T00:00:00Z