about
Transcription-targeted DNA deamination by the AID antibody diversification enzymeLong-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Elucidation of IgH intronic enhancer functions via germ-line deletionSequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory regionThe IgH 3' regulatory region controls somatic hypermutation in germinal center B cellsThe IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.The IgH 3' regulatory region and its implication in lymphomagenesis.AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.The IgH 3' regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate.Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.Interallelic class switch recombination can reverse allelic exclusion and allowtrans-complementation of an IgH locus switching defectThe immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutationPolymorphism of the human alpha1 immunoglobulin gene 3' enhancer hs1,2 and its relation to gene expressionAlleles of the alpha1 immunoglobulin gene 3' enhancer control evolution of IgA nephropathy toward renal failureLocalization of the 3' IgH locus elements that effect long-distance regulation of class switch recombinationThe 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotypeIncreased B cell proliferation and reduced Ig production in DREAM transgenic miceThe Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivoDetecting Rare AID-Induced Mutations in B-Lineage Oncogenes from High-Throughput Sequencing Data Using the Detection of Minor Variants by Error Correction Method
P50
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
@zh
name
Eric Pinaud
@ast
Eric Pinaud
@en
Eric Pinaud
@es
Eric Pinaud
@nl
type
label
Eric Pinaud
@ast
Eric Pinaud
@en
Eric Pinaud
@es
Eric Pinaud
@nl
prefLabel
Eric Pinaud
@ast
Eric Pinaud
@en
Eric Pinaud
@es
Eric Pinaud
@nl
P106
P1153
6602412067
P31
P496
0000-0001-7405-9273