Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease

about

Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease

Item

http://www.wikidata.org/entity/Q57492112

description

article

@en

im Januar 2018 veröffentlichter wissenschaftlicher Artikel

@de

wetenschappelijk artikel

@nl

наукова стаття, опублікована у 2018

@uk

ശാസ്ത്രപ്രബന്ധം

@ml

name

Rationally Designed Variants o ...... operties in Health and Disease

@en

Rationally Designed Variants o ...... operties in Health and Disease

@nl

type

Item

label

Rationally Designed Variants o ...... operties in Health and Disease

@en

Rationally Designed Variants o ...... operties in Health and Disease

@nl

prefLabel

Rationally Designed Variants o ...... operties in Health and Disease

@en

Rationally Designed Variants o ...... operties in Health and Disease

@nl

P1476

Rationally Designed Variants o ...... operties in Health and Disease

@en

P2093

Ulf Dettmer

http://www.w3.org/2001/XMLSchema#string

P2860

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Definition of a molecular pathway mediating α-synuclein neurotoxicity

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

P304

623

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.3389/FNINS.2018.00623

http://www.w3.org/2001/XMLSchema#string

P407

English

P478

http://www.w3.org/2001/XMLSchema#string

P577

2018-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

30319334

http://www.w3.org/2001/XMLSchema#string

P921

Synuclein

P932

6167557

http://www.w3.org/2001/XMLSchema#string