about
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factorA substrate-driven allosteric switch that enhances PDI catalytic activityZinc is a potent and specific inhibitor of IFN-λ3 signalling.Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).Allosteric control of βII-tryptase by a redox active disulfide bond.Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.Control of blood proteins by functional disulfide bonds.Post-translational control of protein function by disulfide bond cleavage.Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.Autoregulation of von Willebrand factor function by a disulfide bond switch.Evaluation of a potential redox switch in blood coagulation tenaseObstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma CellsSynthesis and cytotoxicity of novel sansalvamide A derivativesStructural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1αModels of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancerPreclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models
P50
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P50
description
researcher ORCID ID = 0000-0002-0503-7166
@en
wetenschapper
@nl
name
Kristina M Cook
@ast
Kristina M Cook
@en
Kristina M Cook
@es
Kristina M Cook
@nl
كريستينا سانتشيز كوك
@ar
type
label
Kristina M Cook
@ast
Kristina M Cook
@en
Kristina M Cook
@es
Kristina M Cook
@nl
كريستينا سانتشيز كوك
@ar
prefLabel
Kristina M Cook
@ast
Kristina M Cook
@en
Kristina M Cook
@es
Kristina M Cook
@nl
كريستينا سانتشيز كوك
@ar
P108
P1153
P106
P1153
56117338000
56612847600
7202583323
P31
P496
0000-0002-0503-7166