Prion protein expression level alters regional copper, iron and zinc content in the mouse brain
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Neuronal zinc regulation and the prion proteinSynchrotron radiation X-ray microfluorescence reveals polarized distribution of atomic elements during differentiation of pluripotent stem cellsElemental and chemically specific X-ray fluorescence imaging of biological systemsMetal imaging in neurodegenerative diseases.Deficiency of prion protein induces impaired autophagic flux in neurons.Combined EXAFS and DFT structure calculations provide structural insights into the 1:1 multi-histidine complexes of Cu(II) , Cu(I) , and Zn(II) with the tandem octarepeats of the mammalian prion proteinElevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: roles of copper and DMT1.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationIn situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brainThe role of iron in prion disease and other neurodegenerative diseasesMapping Alterations to the Endogenous Elemental Distribution within the Lateral Ventricles and Choroid Plexus in Brain Disorders Using X-Ray Fluorescence Imaging.Changing iron content of the mouse brain during developmentEffect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sitesZinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interfaceLow copper and high manganese levels in prion protein plaques.Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation.Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zoneAberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese ExposureSelective vulnerability to neurodegenerative disease: the curious case of Prion Protein.New insights into metal interactions with the prion protein: EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion protein.On the nature of the Cu-rich aggregates in brain astrocytes.Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits.Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease.The prion-ZIP connection: From cousins to partners in iron uptake.Metallothioneins in Prion- and Amyloid-Related Diseases.The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.Prion protein facilitates uptake of zinc into neuronal cells.LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion Protein.Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's diseaseAffinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results.Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.Endogenous cellular prion protein regulates contractility of the mouse ileum.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.Prion protein modulates glucose homeostasis by altering intracellular iron.
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Prion protein expression level alters regional copper, iron and zinc content in the mouse brain
description
im Januar 2011 veröffentlichter wissenschaftlicher Artikel
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scientific article published on 24 January 2011
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wetenschappelijk artikel
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наукова стаття, опублікована у 2011
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name
Prion protein expression level ...... inc content in the mouse brain
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Prion protein expression level ...... inc content in the mouse brain
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type
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Prion protein expression level ...... inc content in the mouse brain
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Prion protein expression level ...... inc content in the mouse brain
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Prion protein expression level ...... inc content in the mouse brain
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Prion protein expression level ...... inc content in the mouse brain
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P2093
P2860
P50
P356
P1433
P1476
Prion protein expression level ...... inc content in the mouse brain
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P2093
Frank R Jirik
Gary R Martin
Shigeki Tsutsui
P2860
P304
P356
10.1039/C0MT00037J
P577
2011-01-24T00:00:00Z