Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling

Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling

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http://www.wikidata.org/entity/Q57650081
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells.Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes.Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice.Preclinical evaluation of bortezomib/dipyridamole novel combination as a potential therapeutic modality for hematologic malignancies.Unfolding tyrosine kinase inhibitor sensitivity in chronic myeloid leukemia.Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis.Deregulation of calcium homeostasis in Bcr-Abl-dependent chronic myeloid leukemia.
P2860

Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling

Item
http://www.wikidata.org/entity/Q57650081
description
im Mai 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 09 February 2006
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2006
@uk
name
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@en
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@nl
type
label
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@en
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@nl
prefLabel
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@en
Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@nl
P1433
P1476
P2093
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P31
P356
P407
P433
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P50
P577
P698
P921
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P1433
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Bcr-Abl reduces endoplasmic re ...... -dependent apoptotic signaling
@en
P2093
P304
P31
P356
10.1182/BLOOD-2005-04-1523
P407
P433
P478
P50
P577
P698
P921