Ubiquinone-binding Site Mutations in theSaccharomyces cerevisiaeSuccinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate
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Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and EpigeneticsPhysiological consequences of complex II inhibition for aging, disease, and the mKATP channelThe STF2p hydrophilin from Saccharomyces cerevisiae is required for dehydration stress tolerance.Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiationMutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicolaWarburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.(1)H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems.Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenaseMitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex IIEffects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants.Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactionsStructural basis for malfunction in complex II.Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cellsPlacenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell diseaseThe power of yeast to model diseases of the powerhouse of the cell.Electron-transfer pathways in the heme and quinone-binding domain of complex II (succinate dehydrogenase).Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance.Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells.Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.Red algae lose key mitochondrial genes in response to becoming parasitic.Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemiaSpecific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis inductionYeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome.New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorum.
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P2860
Ubiquinone-binding Site Mutations in theSaccharomyces cerevisiaeSuccinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juli 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2007
@uk
name
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@en
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@nl
type
label
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@en
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@nl
prefLabel
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@en
Ubiquinone-binding Site Mutati ...... the Accumulation of Succinate
@nl
P2093
P2860
P356
P1476
Ubiquinone-binding site mutati ...... the accumulation of succinate
@en
P2093
Bernard D Lemire
Brian D Sykes
Samuel S W Szeto
P2860
P304
27518-27526
P356
10.1074/JBC.M700601200
P407
P577
2007-07-18T00:00:00Z