about
A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.Estimating the evidence of selection and the reliability of inference in unigenic evolution.Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic CholangiocarcinomaThe I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENsDivalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.Engineered CRISPR-Cas9 nucleases with altered PAM specificitiesHigh-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Rapid screening of endonuclease target site preference using a modified bacterial two-plasmid selection.Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA.Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.Discovery of widespread type I and type V CRISPR-Cas inhibitorsEngineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editingStrand-specific contacts and divalent metal ion regulate double-strand break formation by the GIY-YIG homing endonuclease I-BmoIActivities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maizePrediction of off-target activities for the end-to-end design of CRISPR guide RNAsIn vivo engineering of lymphocytes after systemic exosome-associated AAV deliveryVoices in methods developmentHigh levels of AAV vector integration into CRISPR-induced DNA breaksUnconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variantsBroad-spectrum anti-CRISPR proteins facilitate horizontal gene transferAllele-specific gene editing prevents deafness in a model of dominant progressive hearing lossAuthor Correction: Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transferPublisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
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description
researcher ORCID ID = 0000-0002-5469-0655
@en
wetenschapper
@nl
name
Benjamin P Kleinstiver
@ast
Benjamin P Kleinstiver
@en
Benjamin P Kleinstiver
@nl
type
label
Benjamin P Kleinstiver
@ast
Benjamin P Kleinstiver
@en
Benjamin P Kleinstiver
@nl
prefLabel
Benjamin P Kleinstiver
@ast
Benjamin P Kleinstiver
@en
Benjamin P Kleinstiver
@nl
P106
P31
P496
0000-0002-5469-0655