about
Minimal pre-mRNA substrates with natural and converted sites for full-round U insertion and U deletion RNA editing in trypanosomes.Roles for ligases in the RNA editing complex of Trypanosoma brucei: band IV is needed for U-deletion and RNA repair.REH2 RNA helicase in kinetoplastid mitochondria: ribonucleoprotein complexes and essential motifs for unwinding and guide RNA (gRNA) bindingThe impact of mRNA structure on guide RNA targeting in kinetoplastid RNA editingNative mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA compositionRNA editing complex interactions with a site for full-round U deletion in Trypanosoma bruceiRBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction.Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA EditingREH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes.DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes.Trypanosome RNA editing: simple guide RNA features enhance U deletion 100-fold.Distinct functions of two RNA ligases in active Trypanosoma brucei RNA editing complexes.Trypanosoma brucei U insertion and U deletion activities co-purify with an enzymatic editing complex but are differentially optimized.Determinants for association and guide RNA-directed endonuclease cleavage by purified RNA editing complexes from Trypanosoma brucei.Trypanosoma brucei RNA editing: coupled cycles of U deletion reveal processive activity of the editing complex.T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle.Preferential interaction of a 25kDa protein with an A6 pre-mRNA substrate for RNA editing in Trypanosoma brucei.Substrate determinants for RNA editing and editing complex interactions at a site for full-round U insertion.Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editingProtein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomesUnexpected electrophoretic migration of RNA with different 3' termini causes a RNA sizing ambiguity that can be resolved using nuclease P1-generated sequencing laddersRibonuclease activities of trypanosome RNA editing complex directed to cleave specifically at a chosen siteDirect sizing of RNA fragments using RNase-generated standardsRNA-protein interactions in assembled editing complexes in trypanosomes
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description
researcher ORCID ID = 0000-0003-0545-1508
@en
wetenschapper
@nl
name
Jorge Cruz-Reyes
@ast
Jorge Cruz-Reyes
@en
Jorge Cruz-Reyes
@es
Jorge Cruz-Reyes
@nl
type
label
Jorge Cruz-Reyes
@ast
Jorge Cruz-Reyes
@en
Jorge Cruz-Reyes
@es
Jorge Cruz-Reyes
@nl
prefLabel
Jorge Cruz-Reyes
@ast
Jorge Cruz-Reyes
@en
Jorge Cruz-Reyes
@es
Jorge Cruz-Reyes
@nl
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P1153
6701824769
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P31
P496
0000-0003-0545-1508