about
Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobinDosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosisThe nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice--involvement of the soluble guanylate cyclase/K(ATP) pathway.Oxygen-sensing histidine-protein kinases: assays of ligand binding and turnover of response-regulator substrates.The potent anti-cancer activity of Dioclea lasiocarpa lectin.Drug discovery targeting heme-based sensors and their coupled activities.Hydroxyl Radical Generation and DNA Nuclease Activity: A Mechanistic Study Based on a Surface-Immobilized Copper Thioether Clip-Phen Derivative.An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway.An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.Photochemical studies of cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6): Blue light-induced nucleobase binding.Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding.Development of a spectrophotometric assay for cyclase activity.Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy.Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT.[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy.Haem-Based Sensors of O2: Lessons and Perspectives.Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity.Electrochemistry, surface plasmon resonance, and quartz crystal microbalance: an associative study on cytochrome c adsorption on pyridine tail-group monolayers on gold.Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor.The Heme-Based Oxygen Sensor Rhizobium etli FixL: Influence of Auxiliary Ligands on Heme Redox Potential and Implications on the Enzyme Activity.A memory of oxygen binding explains the dose response of the heme-based sensor FixL.Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action.Signal transduction and phosphoryl transfer by a FixL hybrid kinase with low oxygen affinity: importance of the vicinal PAS domain and receiver aspartate.A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator PropertiesPreparation, characterization and structure of ruthenium phosphine complexes containing non-innocent ligandsAsymmetric heterobimetallic mixed-valence complex trans-[(SO3)Co(cyclam)(NCS)Ru(NH3)4(NCS)](BF4): Synthesis and characterizationActivity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infectionMechanism and biological implications of the NO release of cis-[Ru(bpy)2L(NO)](n+) complexes: a key role of physiological thiolsNitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activitiesOxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structureEffect of Crotalus basiliscus snake venom on the redox reaction of myoglobinIn vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensisStructural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)Incorporation of Nitroprusside on Silica Nanoparticles-A Strategy for Safer Use of This NO Donor in TherapyA spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensorAscorbyl and hydroxyl radical generation mediated by a copper complex adsorbed on gold
P50
Q27674077-97873A2D-ADA1-401A-8D89-6E18839C1822Q28486387-50E27AB4-0F2E-4ED9-AD59-BA53E5EB60C0Q35561330-68479993-B058-4AE9-87B1-231B4D3E44E8Q37146630-8A87EA14-C495-416E-870F-A5B1896906D8Q38653523-30594E49-EF89-4EEF-882B-8203934EDE32Q39022261-382A97C2-B6AA-42BE-A10E-C6E51758E289Q39678368-BB5989ED-B831-488C-AE22-E93EBB417E05Q43274632-280B6261-5F8E-44EA-9119-675ADD79A17DQ43636882-C76EBB2E-A289-4EAD-BD1B-A1F677C239D7Q44739712-BD96913E-4FB5-478C-95D6-5E7A2E5CBB91Q46232394-18E37FE0-E537-428C-971B-6002FD26331FQ46333434-EE78FB20-867D-437B-BFBE-B161E5177A53Q46805033-5E6B9D4E-DBDC-435D-B1BD-F43828F91B53Q47413444-EFD9DA30-FE2B-4368-BAB4-AA8EC39F2226Q47699171-DEA857A1-FA14-47BB-BCBE-3A66CE8BA2FCQ47732383-6AA605F2-EFF8-43DE-9D51-A63124D7C107Q48008056-1CE8C7DB-AD7C-464D-A0E9-FBF0CE91904AQ49918434-2D82B4D2-46DF-4924-AFE2-CA242DCEBB51Q50863467-5CFAF07B-63E3-44DE-9667-3E08560B6DC3Q51026851-DE307055-73A8-4A9A-991F-37D4D7D1447EQ51521830-D00015F5-EA14-4646-B518-7F6479A3A084Q51975436-770D1B13-73A0-470C-B8C1-A6411B5F5401Q52616818-6FDE6493-61A7-4FD5-872E-DF023C3AD0B3Q53462040-C0F0FE52-22AB-46F9-B7D7-018C1C1AB7CAQ54460010-74D1F4AE-BC3E-4E84-8FC5-D817BD528A92Q54462185-D586F43F-D719-4FC4-AE57-89442CEEC615Q55333929-F98FF678-7739-4656-ACD1-45E61216812FQ58860517-CF1E86C3-4310-4198-8456-F0A21240C127Q58860617-BB7A4DF2-AD5B-44F7-AEF7-562BA7BE2056Q58860631-AAB36BB3-C110-443A-974F-EBFF5C21358BQ60349585-C91645D9-8FF9-4B99-9B5B-8FBC3CCBB3EBQ83736842-816EEAB7-9E5F-49F7-AE17-FE55DE96B979Q90166696-824774F9-F543-486B-842E-E8371A5A771CQ90661573-87CFA48A-3C72-40F0-B18F-A9A695233C03Q91182792-6EC28450-8F3B-445E-9F45-936E6865BEA0Q91251091-4763BFE2-6082-4A9E-8080-97FC5E80B1DFQ91257185-D3C9B088-834A-4481-A951-D60288680FA3Q91984584-5DDED039-6FA4-4E0B-830B-1B367B040C55Q93120553-E6FF6EB8-4F6B-4169-A85A-BF06392AB0D0Q93193785-FEDAE47C-38A9-4E5A-BC56-235E65ADA70C
P50
description
researcher ORCID ID = 0000-0002-0007-8452
@en
wetenschapper
@nl
name
Eduardo Henrique Silva Sousa
@ast
Eduardo Henrique Silva Sousa
@en
Eduardo Henrique Silva Sousa
@es
Eduardo Henrique Silva Sousa
@nl
type
label
Eduardo Henrique Silva Sousa
@ast
Eduardo Henrique Silva Sousa
@en
Eduardo Henrique Silva Sousa
@es
Eduardo Henrique Silva Sousa
@nl
prefLabel
Eduardo Henrique Silva Sousa
@ast
Eduardo Henrique Silva Sousa
@en
Eduardo Henrique Silva Sousa
@es
Eduardo Henrique Silva Sousa
@nl
P106
P1153
7004889522
P21
P31
P496
0000-0002-0007-8452