The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling
about
Cytochrome P4502C9: an enzyme of major importance in human drug metabolismCrystal structure of human cytochrome P450 2C9 with bound warfarinComparative QSAR analyses of competitive CYP2C9 inhibitors using three-dimensional molecular descriptors.Summary of information on human CYP enzymes: human P450 metabolism data.Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.Metabolism-based drug interactions involving oral azole antifungals in humans.Baseline lipophilicity relationships in human cytochromes P450 associated with drug metabolism.Implications of pharmacogenetics for individualizing drug treatment and for study design.QSAR of cytochrome inhibitors.Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes.Homology modeling and substrate binding study of human CYP2C9 enzyme.Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes.CYP isoform specificity toward drug metabolism: analysis using common feature hypothesis.Investigation of enzyme selectivity in the human CYP2C subfamily: homology modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 crystallographic template.
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P2860
The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling
description
article
@en
im August 1995 veröffentlicher wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 1995
@uk
name
The Substrate Binding Site of ...... vatives and Molecular Modeling
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The Substrate Binding Site of ...... vatives and Molecular Modeling
@nl
type
label
The Substrate Binding Site of ...... vatives and Molecular Modeling
@en
The Substrate Binding Site of ...... vatives and Molecular Modeling
@nl
prefLabel
The Substrate Binding Site of ...... vatives and Molecular Modeling
@en
The Substrate Binding Site of ...... vatives and Molecular Modeling
@nl
P2093
P356
P1433
P1476
The substrate binding site of ...... vatives and molecular modeling
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P2093
P304
10365-10375
P356
10.1021/BI00033A007
P407
P577
1995-08-01T00:00:00Z