Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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wetenschappelijk artikel

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наукова стаття, опублікована в березні 2018

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name

Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Item

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Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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P1476

Homology-Directed Repair and t ...... in Genome Integrity and Cancer

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Chun-Chin Chen

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Elizabeth M Kass

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Maria Jasin

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Pei Xin Lim

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Weiran Feng

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Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation

Purified human BRCA2 stimulates RAD51-mediated recombination

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Mutational processes molding the genomes of 21 breast cancers

Human CtIP promotes DNA end resection

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313-336

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scholarly article

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10.1146/ANNUREV-CANCERBIO-030617-050502

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English

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2018-03-01T00:00:00Z

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30345412

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6193498

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