Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
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Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor proteinMisfolding diverts CFTR from recycling to degradation: quality control at early endosomesX-ray structure of two crystalline forms of a streptomycete ribonuclease with cytotoxic activityImplementation of a k/k0 Method to Identify Long-Range Structure in Transition States during Conformational Folding/Unfolding of ProteinsThe (1)H, (13)C, (15)N resonance assignment, solution structure, and residue level stability of eosinophil cationic protein/RNase 3 determined by NMR spectroscopySignificant stabilization of ribonuclease A by additive effectsStructure and functional studies of the ribonuclease binase Glu43Ala/Phe81Ala mutantCytotoxic ribonucleases: molecular weapons and their targetsAdsorption-induced changes in ribonuclease A structure and enzymatic activity on solid surfaces.NMR structural determinants of eosinophil cationic protein binding to membrane and heparin mimeticsAntitumor activity of ribonuclease multimers created by site-specific covalent tethering.Cancer chemotherapy--ribonucleases to the rescue.Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation.Tumoricidal Activity of RNase A and DNase I.A continuous fluorometric assay for the assessment of MazF ribonuclease activity.Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicityStability and folding of amphibian ribonuclease A superfamily members in comparison with mammalian homologues.Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic.Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity.Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction.Rational design and evaluation of mammalian ribonuclease cytotoxinsOnconase cytotoxicity relies on the distribution of its positive charge.Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.Contribution of the C30/C75 disulfide bond to the biological properties of onconase.Cytotoxic ribonucleases: the dichotomy of Coulombic forces.Design and characterization of an HIV-specific ribonuclease zymogen.Ribonuclease S reduxA study of ribonuclease activity in venom of vietnam cobra.Evaluation of irreversible protein thermal inactivation caused by breakage of disulphide bonds using methanethiosulphonate.Structure-cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants.Creation of a zymogen.Endowing human pancreatic ribonuclease with toxicity for cancer cells.Engineering the refolding pathway and the quaternary structure of seminal ribonuclease by newly introduced disulfide bridges.Thermodynamic analysis of unusually thermostable CutA1 protein from human brain and its protease susceptibility.Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides.A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonucleaseTargeted therapeutic RNases (ImmunoRNases)
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P2860
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2000
@uk
name
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@en
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@nl
type
label
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@en
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@nl
prefLabel
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@en
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@nl
P2860
P356
P1476
Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
@en
P2093
Tony A. Klink
P2860
P304
17463-17467
P356
10.1074/JBC.M001132200
P407
P577
2000-03-27T00:00:00Z