Determination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130
about
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chainA functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptorN-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.Anti-cancer activity of glucosamine through inhibition of N-linked glycosylationCrystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesAnalysis of the disulfide bond arrangement of the HIV-1 envelope protein CON-S gp140 ΔCFI shows variability in the V1 and V2 regions.The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes.N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).Molecular characterization and expression analysis of the putative interleukin 6 receptor (IL-6Rα and glycoprotein-130) in rainbow trout (Oncorhynchus mykiss): salmonid IL-6Rα possesses a polymorphic N-terminal Ig domain with variable numbers of twoKaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism.Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.N-glycans modulate the activation of gp130 in mouse embryonic neural precursor cellsThe dynamics of signal triggering in a gp130-receptor complex.
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Determination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
Determination of the Disulfide ...... Human Signal Transducer gp130
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Determination of the Disulfide ...... Human Signal Transducer gp130
@nl
type
label
Determination of the Disulfide ...... Human Signal Transducer gp130
@en
Determination of the Disulfide ...... Human Signal Transducer gp130
@nl
prefLabel
Determination of the Disulfide ...... Human Signal Transducer gp130
@en
Determination of the Disulfide ...... Human Signal Transducer gp130
@nl
P2093
P2860
P356
P1476
Determination of the Disulfide ...... Human Signal Transducer gp130
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P2093
Lisa M. Connolly
Nathan E. Hall
Robert L. Moritz
P2860
P304
P356
10.1074/JBC.M009979200
P407
P577
2000-11-29T00:00:00Z