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Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1aRenal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy micePhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.Unraveling the human bone microenvironment beyond the classical extracellular matrix proteins: a human bone protein library.Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient miceSystemic and local regulation of the growth plate.Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathwayGhrelin and bone.Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cellsLifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.MicroRNAs in the skeleton: cell-restricted or potent intercellular communicators?Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.Meeting report of the 2016 bone marrow adiposity meeting.Hydroxychloroquine affects bone resorption both in vitro and in vivo.A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses.1α,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization.IFNβ impairs extracellular matrix formation leading to inhibition of mineralization by effects in the early stage of human osteoblast differentiation.1Alpha,25-(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles.Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.Klotho prevents renal calcium loss.Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation.Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice.The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice.Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization.Bone, a dynamic and integrating tissue.The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice.Basic techniques in human mesenchymal stem cell cultures: differentiation into osteogenic and adipogenic lineages, genetic perturbations, and phenotypic analyses.Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats.Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro.TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis.Novel Compound Heterozygous Mutations in the CYP27B1 Gene Lead to Pseudovitamin D-Deficient Rickets.Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat.Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice.
P50
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description
onderzoeker
@nl
researcher, ORCID id # 0000-0003-4403-6497
@en
name
Bram van der Eerden
@ast
Bram van der Eerden
@en
Bram van der Eerden
@es
Bram van der Eerden
@nl
type
label
Bram van der Eerden
@ast
Bram van der Eerden
@en
Bram van der Eerden
@es
Bram van der Eerden
@nl
prefLabel
Bram van der Eerden
@ast
Bram van der Eerden
@en
Bram van der Eerden
@es
Bram van der Eerden
@nl
P106
P31
P496
0000-0003-4403-6497