Cytochromes P450 as useful biocatalysts: addressing the limitations
about
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionVersatile biocatalysis of fungal cytochrome P450 monooxygenasesOxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic AcidsThe Oxygen Dilemma: A Severe Challenge for the Application of Monooxygenases?Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation.A series of hybrid P450 BM3 enzymes with different catalytic activity in the light-initiated hydroxylation of lauric acidDifferences and comparisons of the properties and reactivities of iron(III)-hydroperoxo complexes with saturated coordination sphereSteroid conversion with CYP106A2 - production of pharmaceutically interesting DHEA metabolites.Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes.Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity.Electrocatalysis by subcellular liver fractions bound to carbon nanostructures for stereoselective green drug metabolite synthesis.Directed Evolution of Enzymes for Industrial Biocatalysis.Semirational Protein Engineering of CYP153AM.aq. -CPRBM3 for Efficient Terminal Hydroxylation of Short- to Long-Chain Fatty Acids.Engineering of daidzein 3'-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450.An efficient light-driven P450 BM3 biocatalyst.P450(BM3) (CYP102A1): connecting the dots.Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis.Constructing manmade enzymes for oxygen activation.Chimeric P450 enzymes: activity of artificial redox fusions driven by different reductases for biotechnological applications.Peroxygenase reactions catalyzed by cytochromes P450.Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations.Bacterial whole-cell biocatalysts by surface display of enzymes: toward industrial application.Guidelines for development and implementation of biocatalytic P450 processes.Does compound I vary significantly between isoforms of cytochrome P450?Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1.Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases.Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme.Biotechnological production of caffeic acid by bacterial cytochrome P450 CYP199A2.Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous.Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution.Fatty acid oxidation: systems analysis and applications.Screening for cytochrome P450 expression in Pichia pastoris whole cells by P450-carbon monoxide complex determination.Insights into an efficient light-driven hybrid P450 BM3 enzyme from crystallographic, spectroscopic and biochemical studies.The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1.Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions.Genetic variations of human CYP2D6 in the Chinese Han population.Development of colorimetric HTS assay of cytochrome p450 for ortho-specific hydroxylation, and engineering of CYP102D1 with enhanced catalytic activity and regioselectivity.The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac.
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Cytochromes P450 as useful biocatalysts: addressing the limitations
description
im Januar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 24 January 2011
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у 2011
@uk
name
Cytochromes P450 as useful biocatalysts: addressing the limitations
@en
Cytochromes P450 as useful biocatalysts: addressing the limitations
@nl
type
label
Cytochromes P450 as useful biocatalysts: addressing the limitations
@en
Cytochromes P450 as useful biocatalysts: addressing the limitations
@nl
prefLabel
Cytochromes P450 as useful biocatalysts: addressing the limitations
@en
Cytochromes P450 as useful biocatalysts: addressing the limitations
@nl
P2860
P50
P356
P1476
Cytochromes P450 as useful biocatalysts: addressing the limitations
@en
P2093
Valentin Köhler
P2860
P304
P356
10.1039/C0CC03165H
P407
P577
2011-01-24T00:00:00Z