Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
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We are ageingExendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factorsGlucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferationRegulation of glucose homeostasis by GLP-1Diabetes outfoxed by GLP-1?Mechanisms of action of glucagon-like peptide 1 in the pancreasPancreatic regulation of glucose homeostasisThe required beta cell research for improving treatment of type 2 diabetesExpression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.Functional characterization of N-terminally GFP-tagged GLP-1 receptorcAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cellsPancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and massSecretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway.Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicityDo Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.JNK3 is required for the cytoprotective effect of exendin 4Single dose GLP-1-Tf ameliorates myocardial ischemia/reperfusion injury.Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathwaysGlucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemiaProglucagon-derived peptides: mechanisms of action and therapeutic potential.Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.Differentiating incretin therapies based on structure, activity, and metabolism: focus on liraglutide.Therapeutic Approaches for Preserving or Restoring Pancreatic β-Cell Function and Mass.The role of incretins in glucose homeostasis and diabetes treatment.Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus.Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell massGlucotoxicity and beta-cell failure in type 2 diabetes mellitus.Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expressionAnti-incretin, Anti-proliferative Action of Dopamine on β-CellsGlucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion.Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer.
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P2860
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
description
article
@en
im Juni 1999 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 1999
@uk
name
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@en
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@nl
type
label
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@en
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@nl
prefLabel
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@en
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@nl
P2093
P356
P1433
P1476
Glucagon-like peptide-1 promot ...... activity in beta (INS-1)-cells
@en
P2093
P2888
P304
P356
10.1007/S001250051238
P577
1999-06-21T00:00:00Z