about
A potent integrin antagonist from a small library of cyclic RGD pentapeptide mimics including benzyl-substituted azabicycloalkane amino acids.Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions.Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF ReceptorsInsights into the Binding of Cyclic RGD Peptidomimetics to α5β1 Integrin by using Live-Cell NMR And Computational Studies.Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the αvβ3 Integrin/VEGFR2 Couple and Impairing Tumor-Associated Angiogenesis.Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents.New potent αvβ3 integrin ligands based on azabicycloalkane (γ,α)-dipeptide mimics.Design, synthesis and biological evaluation of novel dimeric and tetrameric cRGD-paclitaxel conjugates for integrin-assisted drug delivery.Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.Cyclic isoDGR and RGD peptidomimetics containing bifunctional diketopiperazine scaffolds are integrin antagonists.Enhancement of the uptake and cytotoxic activity of doxorubicin in cancer cells by novel cRGD-semipeptide-anchoring liposomes.Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors.Design, synthesis, and biological evaluation of novel cRGD-paclitaxel conjugates for integrin-assisted drug delivery.Synthesis of Gd and (68)Ga complexes in conjugation with a conformationally optimized RGD sequence as potential MRI and PET tumor-imaging probes.A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts.Tumor Targeting with an isoDGR-Drug ConjugateMultivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands.Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.Synthesis and cholera toxin binding properties of multivalent GM1 mimics.Cyclic RGD-containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting.Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ₆ Integrin by Biochemical and Molecular Docking Studies.Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction.4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents.Effective targeting of DC-SIGN by α-fucosylamide functionalized gold nanoparticles.Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting.Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin LigandsConjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug DeliverySynthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin αV β3Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate
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P50
description
researcher, ORCID id # 0000-0001-5486-3504
@en
wetenschapper
@nl
name
Daniela Arosio
@ast
Daniela Arosio
@en
Daniela Arosio
@es
Daniela Arosio
@nl
type
label
Daniela Arosio
@ast
Daniela Arosio
@en
Daniela Arosio
@es
Daniela Arosio
@nl
prefLabel
Daniela Arosio
@ast
Daniela Arosio
@en
Daniela Arosio
@es
Daniela Arosio
@nl
P106
P21
P31
P496
0000-0001-5486-3504