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Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNAThe human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3LStructure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease familyEndonucleolytic RNA cleavage by a eukaryotic exosome.RNA channelling by the eukaryotic exosome.hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAsMultiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.Mechanisms of RNA degradation by the eukaryotic exosome.Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism.The eukaryotic RNA exosome: same scaffold but variable catalytic subunits.Catalytic properties of the eukaryotic exosome.Cytoplasmic RNA decay pathways - Enzymes and mechanisms.Comparison of preribosomal RNA processing pathways in yeast, plant and human cells - focus on coordinated action of endo- and exoribonucleases.The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.Up-regulation of human PNPase mRNA by beta-interferon has no effect on protein level in melanoma cell lines.Specific induction and carbon/nitrogen repression of arginine catabolism gene of Aspergillus nidulans--functional in vivo analysis of the otaA promoter.Differential stability of mitochondrial mRNA in HeLa cells.Biochemical and structural bioinformatics studies of fungal CutA nucleotidyltransferases explain their unusual specificity toward CTP and increased tendency for cytidine incorporation at the 3'-terminal positions of synthesized tails.RNA degradation in yeast and human mitochondria.Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system.A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans.Purification of Eukaryotic Exoribonucleases Following Heterologous Expression in Bacteria and Analysis of Their Biochemical Properties by In Vitro Enzymatic AssaysElimination of 01/A'-A0 pre-rRNA processing by-product in human cells involves cooperative action of two nuclear exosome-associated nucleases: RRP6 and DIS3.
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Polish researcher
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cercetător polonez
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chercheur polonais
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investigador polaco
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investigador polaco
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investigador polonès
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polnischer Forscher
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polski naukowiec
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ricercatore polacco
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Rafal Tomecki
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Rafał Tomecki
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Rafał Tomecki
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Rafał Bogusław Tomecki
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Rafał Tomecki
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P1412
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Rafał Tomecki
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P3124
P496
0000-0003-2473-5004
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viaf-62146936744413781656