about
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingRIP2 is a novel NF-kappaB-activating and cell death-inducing kinaseStructural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4.Involvement of presenilins in cell-survival signalling pathways.γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways.Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75(NTR)) mediated glioblastoma cell migration.Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor.Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs).A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.
P50
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P50
description
researcher, ORCID id # 0000-0002-2667-7365
@en
wetenschapper
@nl
name
Justin V McCarthy
@ast
Justin V McCarthy
@en
Justin V McCarthy
@es
Justin V McCarthy
@nl
type
label
Justin V McCarthy
@ast
Justin V McCarthy
@en
Justin V McCarthy
@es
Justin V McCarthy
@nl
prefLabel
Justin V McCarthy
@ast
Justin V McCarthy
@en
Justin V McCarthy
@es
Justin V McCarthy
@nl
P106
P1153
7402958400
P31
P496
0000-0002-2667-7365