about
Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine ModelsThe crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding foldCrystal structure and DNA repair activities of the AP endonuclease from Leishmania majorStructural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinaseβ-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPaseThe Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and DeoxyuridineDesign, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPaseSynthesis and Evaluation of α-Thymidine Analogues as Novel AntimalarialsStructures of adenosine kinase fromTrypanosoma brucei bruceiStructural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonatesSqualene synthase as a target for Chagas disease therapeuticsOn the catalytic mechanism of dimeric dUTPasesCell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma bruceiThe crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPasesStructural and Kinetic Characterization of Thymidine Kinase from Leishmania majorDiscovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural ProductsThe NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cellsSQ109, a new drug lead for Chagas disease.Trypanosomal dUTPases as potential targets for drug design.Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii.High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives.Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coliNovel inhibitors of Trypanosoma cruzi dihydrofolate reductase.The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-4303-5209
@en
name
Dolores Gonzalez-Pacanowska
@ast
Dolores Gonzalez-Pacanowska
@en
Dolores Gonzalez-Pacanowska
@es
Dolores Gonzalez-Pacanowska
@nl
type
label
Dolores Gonzalez-Pacanowska
@ast
Dolores Gonzalez-Pacanowska
@en
Dolores Gonzalez-Pacanowska
@es
Dolores Gonzalez-Pacanowska
@nl
prefLabel
Dolores Gonzalez-Pacanowska
@ast
Dolores Gonzalez-Pacanowska
@en
Dolores Gonzalez-Pacanowska
@es
Dolores Gonzalez-Pacanowska
@nl
P106
P1153
7003851678
P21
P31
P496
0000-0002-4303-5209