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Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidaseThe expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patientsProlyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis.Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells.Possible proton relay pathways in cytochrome c oxidaseBinding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.Glutamic acid 286 in subunit I of cytochrome bo3 is involved in proton translocationProlyl oligopeptidase: a potential target for the treatment of cognitive disorders.Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research.Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome.Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A.Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.L-dopa-induced desensitization depends on 5-hydroxytryptamine imbalance in hemiparkinsonian rats.Characterization of membrane-bound prolyl endopeptidase from brain.Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study.Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction.Demonstration by FTIR that the bo-type ubiquinol oxidase of Escherichia coli contains a heme-copper binuclear center similar to that in cytochrome c oxidase and that proper assembly of the binuclear center requires the cyoE gene product.Are Transglutaminase 2 Inhibitors Able to Reduce Gliadin-Induced Toxicity Related to Celiac Disease? A Proof-of-Concept StudySynthesis and biological evaluation of novel 123I-labeled 4-(4-iodophenyl)butanoyl-l-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivoDeficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac diseasePurification and characterization of two-subunit cytochrome aa3 from Bacillus cereusTwo different aa3-type cytochromes can be purified from the bacterium Bacillus cereusChannelling of dioxygen into the respiratory enzymeA novel cytochrome c oxidase from Rhodobacter sphaeroides that lacks CuAPurification, crystallization and preliminary crystallographic studies of an integral membrane protein, cytochrome bo3 ubiquinol oxidase from Escherichia coliProlyl oligopeptidase in brain function and dysfunctionAng II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-9680-717X
@en
name
Arturo García-Horsman
@ast
Arturo García-Horsman
@en
Arturo García-Horsman
@es
Arturo García-Horsman
@nl
type
label
Arturo García-Horsman
@ast
Arturo García-Horsman
@en
Arturo García-Horsman
@es
Arturo García-Horsman
@nl
prefLabel
Arturo García-Horsman
@ast
Arturo García-Horsman
@en
Arturo García-Horsman
@es
Arturo García-Horsman
@nl
P106
P1153
6603298055
P21
P31
P496
0000-0002-9680-717X