The ADP-Ribosylating CTA1-DD Adjuvant Enhances T Cell-Dependent and Independent Responses by Direct Action on B Cells Involving Anti-Apoptotic Bcl-2- and Germinal Center-Promoting Effects
about
From toxin to adjuvant: the rational design of a vaccine adjuvant vector, CTA1-DD/ISCOM.ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity.The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1/Th17 cellular immune responsesMucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins.The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization.Whole-body autoradiography reveals that the Peptostreptococcus magnus immunoglobulin-binding domains of protein L preferentially target B lymphocytes in the spleen and lymph nodes in vivo.
P2860
The ADP-Ribosylating CTA1-DD Adjuvant Enhances T Cell-Dependent and Independent Responses by Direct Action on B Cells Involving Anti-Apoptotic Bcl-2- and Germinal Center-Promoting Effects
description
article
@en
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 2000
@uk
name
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@en
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@nl
type
label
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@en
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@nl
prefLabel
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@en
The ADP-Ribosylating CTA1-DD A ...... minal Center-Promoting Effects
@nl
P2093
P1476
The ADP-ribosylating CTA1-DD a ...... minal center-promoting effects
@en
P2093
P304
P356
10.4049/JIMMUNOL.164.12.6276
P407
P577
2000-06-01T00:00:00Z