Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
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Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcsKu70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cellsActivation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes VirusActivation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.Genetic evidence that the non-homologous end-joining repair pathway is involved in LINE retrotranspositionThe Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationA noncatalytic function of the ligation complex during nonhomologous end joining.Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes.Detection of alpha-rod protein repeats using a neural network and application to huntingtin.Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceDNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritisATM activation in the presence of oxidative stress.Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown.Ku80 removal from DNA through double strand break-induced ubiquitylation.A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic SubunitDNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombinationThe N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells.A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining.NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)DNA-PK suppresses a p53-independent apoptotic response to DNA damageUnderstanding and re-engineering nucleoprotein machines to cure human disease.Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response.Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.Double-strand breaks and the concept of short- and long-term epigenetic memory.Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.The role and clinical significance of DNA damage response and repair pathways in primary brain tumorsTargeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells.Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1.Cryo-EM structure of the DNA-PK holoenzyme.
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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
description
im Mai 2006 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2006
@uk
name
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
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Three-Dimensional Structure of ...... mplications for DNA DSB Repair
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type
label
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
@en
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
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prefLabel
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
@en
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
@nl
P1433
P1476
Three-Dimensional Structure of ...... mplications for DNA DSB Repair
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P2093
Angel Rivera-Calzada
Laurence H. Pearl
P304
P356
10.1016/J.MOLCEL.2006.04.013
P577
2006-05-01T00:00:00Z