Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma

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Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

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Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

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Item

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Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

@en

Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

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Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

@en

Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

@nl

P1476

Dual BRD4 and AURKA Inhibition ...... and Nonamplified Neuroblastoma

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P2093

Emily Bopp

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Joshua Felgenhauer

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Julia Selich-Anderson

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Laura Tomino

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Nilay Shah

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P2860

Drugging MYCN through an allosteric transition in Aurora kinase A

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding

A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

P304

965-974

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P31

scholarly article

P356

10.1016/J.NEO.2018.08.002

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P407

English

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P478

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P577

2018-10-01T00:00:00Z

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P698

30153557

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P921

cancer research

P932

6111011

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