Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

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Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro

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Q58705933-CD48C6FA-2044-4219-8663-91394C5AC99F

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Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

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wetenschappelijk artikel

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наукова стаття, опублікована в грудні 2018

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Discovery of new chromen-4-one ...... ulating expression of dyskerin

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Discovery of new chromen-4-one ...... ulating expression of dyskerin

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Discovery of new chromen-4-one ...... ulating expression of dyskerin

@en

Discovery of new chromen-4-one ...... ulating expression of dyskerin

@nl

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Discovery of new chromen-4-one ...... ulating expression of dyskerin

@en

Discovery of new chromen-4-one ...... ulating expression of dyskerin

@nl

P1476

Discovery of new chromen-4-one ...... ulating expression of dyskerin

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Jie Quan Wang

http://www.w3.org/2001/XMLSchema#string

Liu Zeng Chen

http://www.w3.org/2001/XMLSchema#string

Meng Di Yang

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Xin Hua Liu

http://www.w3.org/2001/XMLSchema#string

Xing Chen

http://www.w3.org/2001/XMLSchema#string

Xiu Cheng

http://www.w3.org/2001/XMLSchema#string

Yang Wang

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Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Flavonoids: antioxidants or signalling molecules?

Inhibition of human dyskerin as a new approach to target ribosome biogenesis

Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

Acute dyskerin depletion triggers cellular senescence and renders osteosarcoma cells resistant to genotoxic stress-induced apoptosis.

Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.

Dyskerin overexpression in human hepatocellular carcinoma is associated with advanced clinical stage and poor patient prognosis

Dyskerin, telomerase and the DNA damage response.

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1199-1211

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scholarly article

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10.1080/14756366.2018.1466881

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English

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2018-12-01T00:00:00Z

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30132373

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Farmakologi

drug discovery

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6104605

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Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

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P2860

P2860

Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921

P932