Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

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Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

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im Februar 2015 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 01 March 2015

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wetenschappelijk artikel

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наукова стаття, опублікована в лютому 2015

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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P1476

Glutathione trapping of reacti ...... tic metalloporphyrin catalysts

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P2093

Ari Tolonen

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Sampo Mattila

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Toni Lassila

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P2860

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Ticlopidine and clopidogrel.

Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.

Clozapine-induced agranulocytosis. Incidence and risk factors in the United States.

Biomimetic modeling of oxidative drug metabolism : Strategies, advantages and limitations.

Managing the challenge of chemically reactive metabolites in drug development.

Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.

Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.

Metabolism of ticlopidine in rats: identification of the main biliary metabolite as a glutathione conjugate of ticlopidine S-oxide.

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

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521-532

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P31

scholarly article

P356

10.1002/RCM.7129

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Miia Turpeinen

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2015-03-01T00:00:00Z

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P698

26160418

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