Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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im Oktober 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 19 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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P1476

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

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P2093

Angela J Russell

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Carole J R Bataille

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Graham M Wynne

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P2860

MDMX: a novel p53-binding protein with some functional properties of MDM2

Badapple: promiscuity patterns from noisy evidence.

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

p53, the cellular gatekeeper for growth and division

A practical Java tool for small-molecule compound appraisal

A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time

On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

P304

2849-2854

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P31

scholarly article

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10.1021/ACSCHEMBIO.8B00665

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P407

English

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http://www.w3.org/2001/XMLSchema#string

P478

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P50

P577

2018-09-19T00:00:00Z

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P698

30216042

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P921

molecular medicine

P932

6198280

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