High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

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im Oktober 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 11 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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High-throughput screening of a ...... deamidation-resistant mutants

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High-throughput screening of a ...... deamidation-resistant mutants

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High-throughput screening of a ...... deamidation-resistant mutants

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High-throughput screening of a ...... deamidation-resistant mutants

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High-throughput screening of a ...... deamidation-resistant mutants

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High-throughput screening of a ...... deamidation-resistant mutants

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P1476

High-throughput screening of a ...... deamidation-resistant mutants

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Amy Hilderbrand

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Danielle M DiCara

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Gai Ayalon

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Greg A Lazar

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James A Ernst

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Nicholas J Agard

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Nisana Andersen

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Ruby Chan

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P2860

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions

The influence of protein structure on the products emerging from succinimide hydrolysis.

Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer.

Isoaspartate in peptides and proteins: formation, significance, and analysis.

Prediction of protein deamidation rates from primary and three-dimensional structure.

Functional assessment of antibody oxidation by native mass spectrometry.

Formulation and delivery issues for monoclonal antibody therapeutics.

Antibody structure, instability, and formulation.

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1073-1083

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scholarly article

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10.1080/19420862.2018.1504726

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English

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I Hotzel

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2018-09-11T00:00:00Z

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30130444

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P921

immunology

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6204805

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