HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

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HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 11 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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HDAC6 inhibitor TST strengthen ...... via suppressing RTK activation

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Biao Duan

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Bixing Ye

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Jianchao Zheng

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Jie Cui

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Lei Liu

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Luo Gu

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Shixiu Sun

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Wenjie Deng

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Yan Chen

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Yongchang Chen

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The role of HDAC6 in cancer

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

HDAC6: physiological function and its selective inhibitors for cancer treatment

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

PI3K pathway alterations in cancer: variations on a theme

EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells.

Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors.

HDAC6 inhibition restores ciliary expression and decreases tumor growth

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scholarly article

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10.1038/S41419-018-0931-0

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English

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Jun Du

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2018-09-11T00:00:00Z

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30206202

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immunology

cancer research

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6134008

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