Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients

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Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients

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наукова стаття, опублікована у 2018

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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P1476

Mexiletine rescues a mixed bio ...... N406K, found in LQT3 patients

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P2093

Bi-Hua Tan

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Blaise Z Peterson

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David J Tester

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Jonathan C Makielski

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Michael J Ackerman

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Rou-Mu Hu

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Ryan Li

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Tianyu Sun

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P2860

A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations

Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome.

Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Gene-Specific Therapy With Mexiletine Reduces Arrhythmic Events in Patients With Long QT Syndrome Type 3.

Molecular mechanism for an inherited cardiac arrhythmia.

Genetic testing for long-QT syndrome: distinguishing pathogenic mutations from benign variants.

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176-186

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scholarly article

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10.1080/19336950.2018.1475794

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English

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P478

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P577

2018-01-01T00:00:00Z

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29983085

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Biofiseg

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6104686

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